Controlled and Sequential Delivery of Fluorophores from 3D Printed Alginate-PLGA Tubes

Anh Vu Do; Adil Akkouch; Brian Green; Ibrahim Ozbolat; Amer Debabneh; Sean Geary; Aliasger K. Salem

doi:10.1007/s10439-016-1648-9

Controlled and Sequential Delivery of Fluorophores from 3D Printed Alginate-PLGA Tubes

Anh Vu Do, Adil Akkouch, Brian Green, Ibrahim Ozbolat, Amer Debabneh, Sean Geary, Aliasger K. Salem

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Controlled drug delivery systems, that include sequential and/or sustained drug delivery, have been utilized to enhance the therapeutic effects of many current drugs by effectively delivering drugs in a time-dependent and repeatable manner. In this study, with the aid of 3D printing technology, a novel drug delivery device was fabricated and tested to evaluate sequential delivery functionality. With an alginate shell and a poly(lactic-co-glycolic acid) (PLGA) core, the fabricated tubes displayed sequential release of distinct fluorescent dyes and showed no cytotoxicity when incubated with the human embryonic kidney (HEK293) cell line or bone marrow stromal stem cells (BMSC). The controlled differential release of drugs or proteins through such a delivery system has the potential to be used in a wide variety of biomedical applications from treating cancer to regenerative medicine.

Original language	English (US)
Pages (from-to)	297-305
Number of pages	9
Journal	Annals of Biomedical Engineering
Volume	45
Issue number	1
DOIs	https://doi.org/10.1007/s10439-016-1648-9
State	Published - Jan 1 2017

All Science Journal Classification (ASJC) codes

Biomedical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s10439-016-1648-9

Cite this

@article{fa6ac5b306204f2781dca647d91e89d6,

title = "Controlled and Sequential Delivery of Fluorophores from 3D Printed Alginate-PLGA Tubes",

abstract = "Controlled drug delivery systems, that include sequential and/or sustained drug delivery, have been utilized to enhance the therapeutic effects of many current drugs by effectively delivering drugs in a time-dependent and repeatable manner. In this study, with the aid of 3D printing technology, a novel drug delivery device was fabricated and tested to evaluate sequential delivery functionality. With an alginate shell and a poly(lactic-co-glycolic acid) (PLGA) core, the fabricated tubes displayed sequential release of distinct fluorescent dyes and showed no cytotoxicity when incubated with the human embryonic kidney (HEK293) cell line or bone marrow stromal stem cells (BMSC). The controlled differential release of drugs or proteins through such a delivery system has the potential to be used in a wide variety of biomedical applications from treating cancer to regenerative medicine.",

author = "Do, {Anh Vu} and Adil Akkouch and Brian Green and Ibrahim Ozbolat and Amer Debabneh and Sean Geary and Salem, {Aliasger K.}",

note = "Publisher Copyright: {\textcopyright} 2016, Biomedical Engineering Society.",

year = "2017",

month = jan,

day = "1",

doi = "10.1007/s10439-016-1648-9",

language = "English (US)",

volume = "45",

pages = "297--305",

journal = "Annals of Biomedical Engineering",

issn = "0090-6964",

publisher = "Springer Netherlands",

number = "1",

}

TY - JOUR

T1 - Controlled and Sequential Delivery of Fluorophores from 3D Printed Alginate-PLGA Tubes

AU - Do, Anh Vu

AU - Akkouch, Adil

AU - Green, Brian

AU - Ozbolat, Ibrahim

AU - Debabneh, Amer

AU - Geary, Sean

AU - Salem, Aliasger K.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Controlled drug delivery systems, that include sequential and/or sustained drug delivery, have been utilized to enhance the therapeutic effects of many current drugs by effectively delivering drugs in a time-dependent and repeatable manner. In this study, with the aid of 3D printing technology, a novel drug delivery device was fabricated and tested to evaluate sequential delivery functionality. With an alginate shell and a poly(lactic-co-glycolic acid) (PLGA) core, the fabricated tubes displayed sequential release of distinct fluorescent dyes and showed no cytotoxicity when incubated with the human embryonic kidney (HEK293) cell line or bone marrow stromal stem cells (BMSC). The controlled differential release of drugs or proteins through such a delivery system has the potential to be used in a wide variety of biomedical applications from treating cancer to regenerative medicine.

AB - Controlled drug delivery systems, that include sequential and/or sustained drug delivery, have been utilized to enhance the therapeutic effects of many current drugs by effectively delivering drugs in a time-dependent and repeatable manner. In this study, with the aid of 3D printing technology, a novel drug delivery device was fabricated and tested to evaluate sequential delivery functionality. With an alginate shell and a poly(lactic-co-glycolic acid) (PLGA) core, the fabricated tubes displayed sequential release of distinct fluorescent dyes and showed no cytotoxicity when incubated with the human embryonic kidney (HEK293) cell line or bone marrow stromal stem cells (BMSC). The controlled differential release of drugs or proteins through such a delivery system has the potential to be used in a wide variety of biomedical applications from treating cancer to regenerative medicine.

UR - http://www.scopus.com/inward/record.url?scp=84970954326&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84970954326&partnerID=8YFLogxK

U2 - 10.1007/s10439-016-1648-9

DO - 10.1007/s10439-016-1648-9

M3 - Article

C2 - 27234816

AN - SCOPUS:84970954326

SN - 0090-6964

VL - 45

SP - 297

EP - 305

JO - Annals of Biomedical Engineering

JF - Annals of Biomedical Engineering

IS - 1

ER -

Controlled and Sequential Delivery of Fluorophores from 3D Printed Alginate-PLGA Tubes

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this