TY - JOUR
T1 - Controlled and Sequential Delivery of Fluorophores from 3D Printed Alginate-PLGA Tubes
AU - Do, Anh Vu
AU - Akkouch, Adil
AU - Green, Brian
AU - Ozbolat, Ibrahim
AU - Debabneh, Amer
AU - Geary, Sean
AU - Salem, Aliasger K.
N1 - Publisher Copyright:
© 2016, Biomedical Engineering Society.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Controlled drug delivery systems, that include sequential and/or sustained drug delivery, have been utilized to enhance the therapeutic effects of many current drugs by effectively delivering drugs in a time-dependent and repeatable manner. In this study, with the aid of 3D printing technology, a novel drug delivery device was fabricated and tested to evaluate sequential delivery functionality. With an alginate shell and a poly(lactic-co-glycolic acid) (PLGA) core, the fabricated tubes displayed sequential release of distinct fluorescent dyes and showed no cytotoxicity when incubated with the human embryonic kidney (HEK293) cell line or bone marrow stromal stem cells (BMSC). The controlled differential release of drugs or proteins through such a delivery system has the potential to be used in a wide variety of biomedical applications from treating cancer to regenerative medicine.
AB - Controlled drug delivery systems, that include sequential and/or sustained drug delivery, have been utilized to enhance the therapeutic effects of many current drugs by effectively delivering drugs in a time-dependent and repeatable manner. In this study, with the aid of 3D printing technology, a novel drug delivery device was fabricated and tested to evaluate sequential delivery functionality. With an alginate shell and a poly(lactic-co-glycolic acid) (PLGA) core, the fabricated tubes displayed sequential release of distinct fluorescent dyes and showed no cytotoxicity when incubated with the human embryonic kidney (HEK293) cell line or bone marrow stromal stem cells (BMSC). The controlled differential release of drugs or proteins through such a delivery system has the potential to be used in a wide variety of biomedical applications from treating cancer to regenerative medicine.
UR - http://www.scopus.com/inward/record.url?scp=84970954326&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84970954326&partnerID=8YFLogxK
U2 - 10.1007/s10439-016-1648-9
DO - 10.1007/s10439-016-1648-9
M3 - Article
C2 - 27234816
AN - SCOPUS:84970954326
SN - 0090-6964
VL - 45
SP - 297
EP - 305
JO - Annals of Biomedical Engineering
JF - Annals of Biomedical Engineering
IS - 1
ER -
