TY - JOUR
T1 - Copper-catalysed cross-coupling
T2 - An untapped potential
AU - Thapa, Surendra
AU - Shrestha, Bijay
AU - Gurung, Santosh K.
AU - Giri, Ramesh
N1 - Publisher Copyright:
© The Royal Society of Chemistry 2015.
PY - 2015/5/7
Y1 - 2015/5/7
N2 - Copper is emerging as a viable catalytic metal for cross-coupling reactions to construct carbon-carbon (C-C) bonds. Recent revelations that Cu-catalysts can execute with high efficacy the cross-couplings of a variety of organometallic reagents, including organomagnesium, organoboron, organosilicon, organoindium and organomanganese, with alkyl, aryl and heteroaryl halides clearly demonstrate the versatility of Cu-based catalytic systems in conducting these reactions. In addition, Cu-catalysts are exhibiting a unique reactivity pattern that allows ligandless cross-coupling for aryl-heteroaryl and heteroaryl-heteroaryl bond formation, a transformation that generally requires special custom-designed ligands with Pd-catalysts. This review summarises early discoveries and subsequent advancements made in the area of Cu-catalysed cross-couplings of organometallic reagents with organohalides to form C-C bonds.
AB - Copper is emerging as a viable catalytic metal for cross-coupling reactions to construct carbon-carbon (C-C) bonds. Recent revelations that Cu-catalysts can execute with high efficacy the cross-couplings of a variety of organometallic reagents, including organomagnesium, organoboron, organosilicon, organoindium and organomanganese, with alkyl, aryl and heteroaryl halides clearly demonstrate the versatility of Cu-based catalytic systems in conducting these reactions. In addition, Cu-catalysts are exhibiting a unique reactivity pattern that allows ligandless cross-coupling for aryl-heteroaryl and heteroaryl-heteroaryl bond formation, a transformation that generally requires special custom-designed ligands with Pd-catalysts. This review summarises early discoveries and subsequent advancements made in the area of Cu-catalysed cross-couplings of organometallic reagents with organohalides to form C-C bonds.
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U2 - 10.1039/c5ob00200a
DO - 10.1039/c5ob00200a
M3 - Article
AN - SCOPUS:84928652729
SN - 1477-0520
VL - 13
SP - 4816
EP - 4827
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
IS - 17
ER -