TY - JOUR
T1 - Correlating metabolic activity with cellular proliferation in follicular lymphomas
AU - Tang, Bingfeng
AU - Malysz, Jozef
AU - Douglas-Nikitin, Vonda
AU - Zekman, Richard
AU - Wong, Regina Heather
AU - Jaiyesimi, Ishmael
AU - Wong, Ching Yee Oliver
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2009
Y1 - 2009
N2 - Purpose: The aim of this study was to correlate metabolic behavior of follicular lymphoma with proliferative index (Ki67). Materials and Methods: Pre-treatment 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography-computed tomography scans of 23 patients with pathologic diagnosis of follicular lymphoma were retrospectively analyzed together with Ki67. The maximal standardized uptake value (SUV) was measured and corrected to glucose level of 100 mg/dl over the biopsy region (BxSUV100) and at the highest tumor activity of the body (BmSUV100). Results: BxSUV100 was significantly correlated with Ki67 (p=0.037). There was an increasing trend of metabolic activity across the pathologic grades of follicular lymphomas. BmSUV100 and BxSUV100 were also significantly different (p<0.0005), suggesting potential pitfalls of sampling error by histology. Conclusion: The increasing trend of metabolic activity across follicular lymphoma grades correlates with cellular proliferation. The metabolic information from positron emission tomography-computed tomography may offer another useful parameter in the management of follicular lymphomas.
AB - Purpose: The aim of this study was to correlate metabolic behavior of follicular lymphoma with proliferative index (Ki67). Materials and Methods: Pre-treatment 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography-computed tomography scans of 23 patients with pathologic diagnosis of follicular lymphoma were retrospectively analyzed together with Ki67. The maximal standardized uptake value (SUV) was measured and corrected to glucose level of 100 mg/dl over the biopsy region (BxSUV100) and at the highest tumor activity of the body (BmSUV100). Results: BxSUV100 was significantly correlated with Ki67 (p=0.037). There was an increasing trend of metabolic activity across the pathologic grades of follicular lymphomas. BmSUV100 and BxSUV100 were also significantly different (p<0.0005), suggesting potential pitfalls of sampling error by histology. Conclusion: The increasing trend of metabolic activity across follicular lymphoma grades correlates with cellular proliferation. The metabolic information from positron emission tomography-computed tomography may offer another useful parameter in the management of follicular lymphomas.
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U2 - 10.1007/s11307-009-0226-z
DO - 10.1007/s11307-009-0226-z
M3 - Article
C2 - 19430847
AN - SCOPUS:68449090032
SN - 1536-1632
VL - 11
SP - 296
EP - 302
JO - Molecular Imaging and Biology
JF - Molecular Imaging and Biology
IS - 5
ER -
