Correlation between serum and adipose tissue levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin in 50 persons from Missouri

D. G. Patterson; L. L. Needham; J. L. Pirkle; D. W. Roberts; J. Bagby; W. A. Garrett; J. S. Andrews; H. Falk; J. T. Bernert; E. J. Sampson; V. N. Houk

doi:10.1007/BF01056017

Correlation between serum and adipose tissue levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin in 50 persons from Missouri

D. G. Patterson
, L. L. Needham
, J. L. Pirkle
, D. W. Roberts
, J. Bagby
, W. A. Garrett
, J. S. Andrews
, H. Falk
, J. T. Bernert
, E. J. Sampson
, V. N. Houk

Forensic Science Program

Research output: Contribution to journal › Article › peer-review

145 Scopus citations

Abstract

Paired human serum and adipose tissue samples were analyzed from 50 persons for 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) by high-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS). On a lipid weight basis, the range of values in adipose tissue spanned approximately 2.5 orders of magnitude, from 3.3 to 969 parts per trillion (ppt). After adjusting the adipose tissue 2,3,7,8-TCDD levels for total lipid content and the serum 2,3,7,8-TCDD levels for total lipid content, the mean of the partitioning ratio of adipose tissue to serum 2,3,7,8-TCDD was 1.09 (standard deviation = 0.385, standard error = 0.060). On this same total lipid weight basis, the adipose tissue and serum levels of 2,3,7,8-TCDD were highly correlated, r = 0.98. The high correlation between adipose tissue and serum 2,3,7,8-TCDD levels in this study indicates that serum 2,3,7,8-TCDD is a valid measurement of 2,3,7,8-TCDD body burden concentration.

Original language	English (US)
Pages (from-to)	139-143
Number of pages	5
Journal	Archives of Environmental Contamination and Toxicology
Volume	17
Issue number	2
DOIs	https://doi.org/10.1007/BF01056017
State	Published - Mar 1988

All Science Journal Classification (ASJC) codes

Toxicology
Pollution
Health, Toxicology and Mutagenesis

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10.1007/BF01056017

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Patterson, D. G., Needham, L. L., Pirkle, J. L., Roberts, D. W., Bagby, J., Garrett, W. A., Andrews, J. S., Falk, H., Bernert, J. T., Sampson, E. J., & Houk, V. N. (1988). Correlation between serum and adipose tissue levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin in 50 persons from Missouri. Archives of Environmental Contamination and Toxicology, 17(2), 139-143. https://doi.org/10.1007/BF01056017

@article{8bffdc95fc974319952e31f263a59d4e,

title = "Correlation between serum and adipose tissue levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin in 50 persons from Missouri",

abstract = "Paired human serum and adipose tissue samples were analyzed from 50 persons for 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) by high-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS). On a lipid weight basis, the range of values in adipose tissue spanned approximately 2.5 orders of magnitude, from 3.3 to 969 parts per trillion (ppt). After adjusting the adipose tissue 2,3,7,8-TCDD levels for total lipid content and the serum 2,3,7,8-TCDD levels for total lipid content, the mean of the partitioning ratio of adipose tissue to serum 2,3,7,8-TCDD was 1.09 (standard deviation = 0.385, standard error = 0.060). On this same total lipid weight basis, the adipose tissue and serum levels of 2,3,7,8-TCDD were highly correlated, r = 0.98. The high correlation between adipose tissue and serum 2,3,7,8-TCDD levels in this study indicates that serum 2,3,7,8-TCDD is a valid measurement of 2,3,7,8-TCDD body burden concentration.",

author = "Patterson, \{D. G.\} and Needham, \{L. L.\} and Pirkle, \{J. L.\} and Roberts, \{D. W.\} and J. Bagby and Garrett, \{W. A.\} and Andrews, \{J. S.\} and H. Falk and Bernert, \{J. T.\} and Sampson, \{E. J.\} and Houk, \{V. N.\}",

year = "1988",

month = mar,

doi = "10.1007/BF01056017",

language = "English (US)",

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Patterson, DG, Needham, LL, Pirkle, JL, Roberts, DW, Bagby, J, Garrett, WA, Andrews, JS, Falk, H, Bernert, JT, Sampson, EJ & Houk, VN 1988, 'Correlation between serum and adipose tissue levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin in 50 persons from Missouri', Archives of Environmental Contamination and Toxicology, vol. 17, no. 2, pp. 139-143. https://doi.org/10.1007/BF01056017

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T1 - Correlation between serum and adipose tissue levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin in 50 persons from Missouri

AU - Patterson, D. G.

AU - Needham, L. L.

AU - Pirkle, J. L.

AU - Roberts, D. W.

AU - Bagby, J.

AU - Garrett, W. A.

AU - Andrews, J. S.

AU - Falk, H.

AU - Bernert, J. T.

AU - Sampson, E. J.

AU - Houk, V. N.

PY - 1988/3

Y1 - 1988/3

N2 - Paired human serum and adipose tissue samples were analyzed from 50 persons for 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) by high-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS). On a lipid weight basis, the range of values in adipose tissue spanned approximately 2.5 orders of magnitude, from 3.3 to 969 parts per trillion (ppt). After adjusting the adipose tissue 2,3,7,8-TCDD levels for total lipid content and the serum 2,3,7,8-TCDD levels for total lipid content, the mean of the partitioning ratio of adipose tissue to serum 2,3,7,8-TCDD was 1.09 (standard deviation = 0.385, standard error = 0.060). On this same total lipid weight basis, the adipose tissue and serum levels of 2,3,7,8-TCDD were highly correlated, r = 0.98. The high correlation between adipose tissue and serum 2,3,7,8-TCDD levels in this study indicates that serum 2,3,7,8-TCDD is a valid measurement of 2,3,7,8-TCDD body burden concentration.

AB - Paired human serum and adipose tissue samples were analyzed from 50 persons for 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) by high-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS). On a lipid weight basis, the range of values in adipose tissue spanned approximately 2.5 orders of magnitude, from 3.3 to 969 parts per trillion (ppt). After adjusting the adipose tissue 2,3,7,8-TCDD levels for total lipid content and the serum 2,3,7,8-TCDD levels for total lipid content, the mean of the partitioning ratio of adipose tissue to serum 2,3,7,8-TCDD was 1.09 (standard deviation = 0.385, standard error = 0.060). On this same total lipid weight basis, the adipose tissue and serum levels of 2,3,7,8-TCDD were highly correlated, r = 0.98. The high correlation between adipose tissue and serum 2,3,7,8-TCDD levels in this study indicates that serum 2,3,7,8-TCDD is a valid measurement of 2,3,7,8-TCDD body burden concentration.

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Correlation between serum and adipose tissue levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin in 50 persons from Missouri

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