Correlation of aromatase activity with histological differentiation of breast cancer - A morphometric analysis

Allan Lipton; Richard J. Santen; Steven J. Santner; Harold A. Harvey; Deborah White-Hershey; Mary J. Bartholomew; Francis E. Sharkey

doi:10.1007/BF01805737

Correlation of aromatase activity with histological differentiation of breast cancer - A morphometric analysis

Allan Lipton, Richard J. Santen, Steven J. Santner, Harold A. Harvey, Deborah White-Hershey, Mary J. Bartholomew, Francis E. Sharkey

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9 Scopus citations

Abstract

Differentiation is a term that indicates the degree to which a tumor resembles histologically the tissue or cell of origin. A system to quantitate the proportion of breast cancer cells participating in glandular differentiation or remaining within ducts was employed. The degree of tumor differentiation of 58 primary breast cancers was correlated with estrogen (ER) and progesterone receptors (PR) and tumor aromatase activity. There was a significant association between tumor differentiation (≥2% cancer cells exhibiting glandular differentiation) and the presence of ER or PR in tumors. Conversely, there was no correlation between tumor differentiation and measurable tumor aromatase activity.

Original language	English (US)
Pages (from-to)	31-35
Number of pages	5
Journal	Breast Cancer Research and Treatment
Volume	12
Issue number	1
DOIs	https://doi.org/10.1007/BF01805737
State	Published - Sep 1 1988

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1007/BF01805737

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abstract = "Differentiation is a term that indicates the degree to which a tumor resembles histologically the tissue or cell of origin. A system to quantitate the proportion of breast cancer cells participating in glandular differentiation or remaining within ducts was employed. The degree of tumor differentiation of 58 primary breast cancers was correlated with estrogen (ER) and progesterone receptors (PR) and tumor aromatase activity. There was a significant association between tumor differentiation (≥2% cancer cells exhibiting glandular differentiation) and the presence of ER or PR in tumors. Conversely, there was no correlation between tumor differentiation and measurable tumor aromatase activity.",

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AU - Lipton, Allan

AU - Santen, Richard J.

AU - Santner, Steven J.

AU - Harvey, Harold A.

AU - White-Hershey, Deborah

AU - Bartholomew, Mary J.

AU - Sharkey, Francis E.

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N2 - Differentiation is a term that indicates the degree to which a tumor resembles histologically the tissue or cell of origin. A system to quantitate the proportion of breast cancer cells participating in glandular differentiation or remaining within ducts was employed. The degree of tumor differentiation of 58 primary breast cancers was correlated with estrogen (ER) and progesterone receptors (PR) and tumor aromatase activity. There was a significant association between tumor differentiation (≥2% cancer cells exhibiting glandular differentiation) and the presence of ER or PR in tumors. Conversely, there was no correlation between tumor differentiation and measurable tumor aromatase activity.

AB - Differentiation is a term that indicates the degree to which a tumor resembles histologically the tissue or cell of origin. A system to quantitate the proportion of breast cancer cells participating in glandular differentiation or remaining within ducts was employed. The degree of tumor differentiation of 58 primary breast cancers was correlated with estrogen (ER) and progesterone receptors (PR) and tumor aromatase activity. There was a significant association between tumor differentiation (≥2% cancer cells exhibiting glandular differentiation) and the presence of ER or PR in tumors. Conversely, there was no correlation between tumor differentiation and measurable tumor aromatase activity.

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Correlation of aromatase activity with histological differentiation of breast cancer - A morphometric analysis

Abstract

All Science Journal Classification (ASJC) codes

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