TY - JOUR
T1 - Corrigendum
T2 - A small molecule inhibitor of Notch1 modulates stemness and suppresses breast cancer cell growth (Frontiers in Pharmacology, (2023), 14, (1150774), 10.3389/fphar.2023.1150774)
AU - Saran, Uttara
AU - Chandrasekaran, Balaji
AU - Tyagi, Ashish
AU - Shukla, Vaibhav
AU - Singh, Amandeep
AU - Sharma, Arun K.
AU - Damodaran, Chendil
N1 - Publisher Copyright:
Copyright © 2024 Saran, Chandrasekaran, Tyagi, Shukla, Singh, Sharma and Damodaran.
PY - 2024
Y1 - 2024
N2 - In the published article, there was an error in Figure 9 as published. Specifically, in Figure 9D, the same image was repeated for both ALDH- HES1 (Veh) and ALDH + Ki67 (ASR490). The correct IHC image for ALDH- HES1 (Veh) has been updated. The corrected Figure 9 and its caption appear below. ASR490 reduces the tumor burden of xenotransplanted breast tumors. (A) Oral administration of ASR490 (25 mg/kg) significantly inhibited the growth of ALDH− and ALDH+ xenotransplanted tumors (n = 6, *p < 0.01, ***p < 0.001). (B) Tumor weight of vehicle and ASR490 treated ALDH− and ALDH+ tumors. (C) Western blots performed for Notch1-NICD and HES1 on vehicle and ASR490-treated ALDH− and ALDH+ tumors. (D) IHC analyses was performed on vehicle and ASR490-treated ALDH− and ALDH+ tumors to evaluate the expressions of Notch1-NICD, HES1, and Ki67 (proliferation marker). p values were calculated using a two-sided Student’s t-test. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
AB - In the published article, there was an error in Figure 9 as published. Specifically, in Figure 9D, the same image was repeated for both ALDH- HES1 (Veh) and ALDH + Ki67 (ASR490). The correct IHC image for ALDH- HES1 (Veh) has been updated. The corrected Figure 9 and its caption appear below. ASR490 reduces the tumor burden of xenotransplanted breast tumors. (A) Oral administration of ASR490 (25 mg/kg) significantly inhibited the growth of ALDH− and ALDH+ xenotransplanted tumors (n = 6, *p < 0.01, ***p < 0.001). (B) Tumor weight of vehicle and ASR490 treated ALDH− and ALDH+ tumors. (C) Western blots performed for Notch1-NICD and HES1 on vehicle and ASR490-treated ALDH− and ALDH+ tumors. (D) IHC analyses was performed on vehicle and ASR490-treated ALDH− and ALDH+ tumors to evaluate the expressions of Notch1-NICD, HES1, and Ki67 (proliferation marker). p values were calculated using a two-sided Student’s t-test. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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U2 - 10.3389/fphar.2024.1420266
DO - 10.3389/fphar.2024.1420266
M3 - Comment/debate
C2 - 38860169
AN - SCOPUS:85195522203
SN - 1663-9812
VL - 15
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
M1 - 1420266
ER -