Corrigendum: A small molecule inhibitor of Notch1 modulates stemness and suppresses breast cancer cell growth (Frontiers in Pharmacology, (2023), 14, (1150774), 10.3389/fphar.2023.1150774)

Uttara Saran, Balaji Chandrasekaran, Ashish Tyagi, Vaibhav Shukla, Amandeep Singh, Arun K. Sharma, Chendil Damodaran

Research output: Contribution to journalComment/debatepeer-review

Abstract

In the published article, there was an error in Figure 9 as published. Specifically, in Figure 9D, the same image was repeated for both ALDH- HES1 (Veh) and ALDH + Ki67 (ASR490). The correct IHC image for ALDH- HES1 (Veh) has been updated. The corrected Figure 9 and its caption appear below. ASR490 reduces the tumor burden of xenotransplanted breast tumors. (A) Oral administration of ASR490 (25 mg/kg) significantly inhibited the growth of ALDH and ALDH+ xenotransplanted tumors (n = 6, *p < 0.01, ***p < 0.001). (B) Tumor weight of vehicle and ASR490 treated ALDH and ALDH+ tumors. (C) Western blots performed for Notch1-NICD and HES1 on vehicle and ASR490-treated ALDH and ALDH+ tumors. (D) IHC analyses was performed on vehicle and ASR490-treated ALDH and ALDH+ tumors to evaluate the expressions of Notch1-NICD, HES1, and Ki67 (proliferation marker). p values were calculated using a two-sided Student’s t-test. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Original languageEnglish (US)
Article number1420266
JournalFrontiers in Pharmacology
Volume15
DOIs
StatePublished - 2024

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

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