TY - JOUR
T1 - Cortical gray and subcortical white matter associations in Parkinson's disease
AU - Sterling, Nicholas W.
AU - Du, Guangwei
AU - Lewis, Mechelle M.
AU - Swavely, Steven
AU - Kong, Lan
AU - Styner, Martin
AU - Huang, Xuemei
N1 - Funding Information:
We would like to express our gratitude to all the participants who volunteered for this study. We acknowledge the magnetic resoanance imaging technical support of Mr Jeffery Vesek and the assistance of study coordinators Mss. Eleanore Hernandez, Brittany Jones, Melissa Santos, and Raghda Clayiff. We thank Professor Richard Mailman for suggestions regarding the preparation of this manuscript. This study was funded by the National Institute of Neurological Disorders and Stroke ( NS060722 and NS082151 to XH), the Hershey Medical Center GCRC ( NIH M01RR10732 ), GCRC Construction Grant ( C06RR016499 ), Pennsylvania Department of Health Tobacco CURE Funds , and the intramural research program of the National Institutes of Health and the National Institute of Environmental Health Sciences (Z01-ES-101986) . Statistical analysis was performed by NWS. Author contributions—NWS: conception, organization, and execution of research project; design, execution, and review and critique of statistical analysis; writing of first draft and review and critique of manuscript. GD: conception, organization, and execution of research project; design and review and critique of statistical analysis; review and critique of manuscript. MML: conception, organization, and execution of research project; review and critique of statistical analysis; writing of first draft and review and critique of manuscript. SS: organization and execution of research project; review and critique of manuscript. LK: conception, organization, and execution of research project; design, execution, and review and critique of statistical analysis; review and critique of manuscript. MS: conception, organization, and execution of research project; review and critique of statistical analysis; review and critique of manuscript. XH: conception, organization, and execution research project; design and review and critique of statistical analysis; writing of first draft and review and critique of manuscript.
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Cortical atrophy has been documented in both Parkinson's disease (PD) and healthy aging, but its relationship to changes in subcortical white matter is unknown. This was investigated by obtaining T1- and diffusion-weighted images from 76 PD and 70 controls at baseline and 18 and 36 months, from which cortical volumes and underlying subcortical white matter axial diffusivity (AD), radial diffusivity (RD), and fractional anisotropy (FA) were determined. Twelve of 69 cortical subregions had significant group differences, and for these, underlying subcortical white matter was explored. At baseline, higher cortical volumes were significantly correlated with lower underlying subcortical white matter AD, RD, and higher FA (ps ≤ 0.017) in PD. Longitudinally, higher rates of cortical atrophy in PD were associated with increased rates of change in AD RD, and FA values (ps ≤ 0.0013) in 2 subregions explored. The significant gray-white matter associations were not found in controls. Thus, unlike healthy aging, cortical atrophy and subcortical white matter changes may not be independent events in PD.
AB - Cortical atrophy has been documented in both Parkinson's disease (PD) and healthy aging, but its relationship to changes in subcortical white matter is unknown. This was investigated by obtaining T1- and diffusion-weighted images from 76 PD and 70 controls at baseline and 18 and 36 months, from which cortical volumes and underlying subcortical white matter axial diffusivity (AD), radial diffusivity (RD), and fractional anisotropy (FA) were determined. Twelve of 69 cortical subregions had significant group differences, and for these, underlying subcortical white matter was explored. At baseline, higher cortical volumes were significantly correlated with lower underlying subcortical white matter AD, RD, and higher FA (ps ≤ 0.017) in PD. Longitudinally, higher rates of cortical atrophy in PD were associated with increased rates of change in AD RD, and FA values (ps ≤ 0.0013) in 2 subregions explored. The significant gray-white matter associations were not found in controls. Thus, unlike healthy aging, cortical atrophy and subcortical white matter changes may not be independent events in PD.
UR - http://www.scopus.com/inward/record.url?scp=84993960696&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84993960696&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2016.09.015
DO - 10.1016/j.neurobiolaging.2016.09.015
M3 - Article
C2 - 27776262
AN - SCOPUS:84993960696
SN - 0197-4580
VL - 49
SP - 100
EP - 108
JO - Neurobiology of Aging
JF - Neurobiology of Aging
ER -