Costimulation requirements for antiviral CD8⁺ T cells differ for acute and persistent phases of polyoma virus infection

Keyphrases

• Acute Infection 20%
• Age of Infection 20%
• CD28 100%
• CD28 Costimulation 20%
• CD40 Ligand (CD40L) 80%
• CD8+ T 20%
• CD8+ T Cell Response 40%
• CD8+ T Cells 100%
• Cell Surface 20%
• Costimulation 100%
• Costimulation Blockade 40%
• Costimulatory Molecules 20%
• Gene Knockout 20%
• Humoral Response 20%
• IgG Titer 40%
• Infected Mice 20%
• Latently Infected 20%
• Microenvironment 20%
• Mouse Strain 20%
• Multiple Organs 20%
• OR Genes 20%
• Persistent Infection 20%
• Persistent Virus Infection 60%
• Polyoma 60%
• Polyomavirus 100%
• Proviral DNA 20%
• Response Control 20%
• Serum IgG 40%
• Surface Phenotype 20%
• T Cell Response 20%
• Viral Control 20%
• Viral Infection 20%
• Viral Persistence 20%
• Virus Infection 100%
• Virus-specific 20%
• Virus-specific CD8+ T Cells 60%

Immunology and Microbiology

• CD28 66%
• CD40 Ligand 55%
• CD8 11%
• Cell Surface 11%
• Cytotoxic T-Cell 100%
• Gene Knockout 11%
• Humoral Immunity 11%
• Mouse 11%
• Mouse Strain 11%
• Murine Polyomavirus 11%
• Polyomavirus 100%
• T Cell 11%
• Titer 22%
• Viral Disease 100%