Coupled flow-structure-biochemistry simulations of dynamic systems of blood cells using an adaptive surface tracking method

M. H. Hoskins; R. F. Kunz; J. E. Bistline; C. Dong

doi:10.1016/j.jfluidstructs.2009.02.002

Coupled flow-structure-biochemistry simulations of dynamic systems of blood cells using an adaptive surface tracking method

M. H. Hoskins, R. F. Kunz, J. E. Bistline, C. Dong

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

A method for the computation of low-Reynolds number dynamic blood cell systems is presented. The specific system of interest here is interaction between cancer cells and white blood cells in an experimental flow system. Fluid dynamics, structural mechanics, six-degree-of-freedom motion control, and surface biochemistry analysis components are coupled in the context of adaptive octree-based grid generation. Analytical and numerical verification of the quasi-steady assumption for the fluid mechanics is presented. The capabilities of the technique are demonstrated by presenting several three-dimensional cell system simulations, including the collision/interaction between a cancer cell and an endothelium adherent polymorphonuclear leukocyte (PMN) cell in a shear flow.

Original language	English (US)
Pages (from-to)	936-953
Number of pages	18
Journal	Journal of Fluids and Structures
Volume	25
Issue number	5
DOIs	https://doi.org/10.1016/j.jfluidstructs.2009.02.002
State	Published - Jul 2009

All Science Journal Classification (ASJC) codes

Mechanical Engineering

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10.1016/j.jfluidstructs.2009.02.002

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@article{7574708c5ff44429bd2feb28a1f0a781,

title = "Coupled flow-structure-biochemistry simulations of dynamic systems of blood cells using an adaptive surface tracking method",

abstract = "A method for the computation of low-Reynolds number dynamic blood cell systems is presented. The specific system of interest here is interaction between cancer cells and white blood cells in an experimental flow system. Fluid dynamics, structural mechanics, six-degree-of-freedom motion control, and surface biochemistry analysis components are coupled in the context of adaptive octree-based grid generation. Analytical and numerical verification of the quasi-steady assumption for the fluid mechanics is presented. The capabilities of the technique are demonstrated by presenting several three-dimensional cell system simulations, including the collision/interaction between a cancer cell and an endothelium adherent polymorphonuclear leukocyte (PMN) cell in a shear flow.",

author = "Hoskins, {M. H.} and Kunz, {R. F.} and Bistline, {J. E.} and C. Dong",

note = "Funding Information: The authors acknowledge and appreciate complimentary software licenses provided to the principal author by CEI, Inc. (Harpoon and Ensight) and ACUSIM Software, Inc. (AcuSolve) for her Ph.D. research, of which the present work is a component. The principal author was supported by an Educational and Foundational Research grant from the Pennsylvania State University Applied Research Laboratory. Support under NIH (NIH CA125707) and NSF (CBET-0729091) were also provided. Software assistance and discussions with Steve Cosgrove, Dave Corson, and Rob Campbell also benefited this work.",

year = "2009",

month = jul,

doi = "10.1016/j.jfluidstructs.2009.02.002",

language = "English (US)",

volume = "25",

pages = "936--953",

journal = "Journal of Fluids and Structures",

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AU - Hoskins, M. H.

AU - Kunz, R. F.

AU - Bistline, J. E.

AU - Dong, C.

N1 - Funding Information: The authors acknowledge and appreciate complimentary software licenses provided to the principal author by CEI, Inc. (Harpoon and Ensight) and ACUSIM Software, Inc. (AcuSolve) for her Ph.D. research, of which the present work is a component. The principal author was supported by an Educational and Foundational Research grant from the Pennsylvania State University Applied Research Laboratory. Support under NIH (NIH CA125707) and NSF (CBET-0729091) were also provided. Software assistance and discussions with Steve Cosgrove, Dave Corson, and Rob Campbell also benefited this work.

PY - 2009/7

Y1 - 2009/7

N2 - A method for the computation of low-Reynolds number dynamic blood cell systems is presented. The specific system of interest here is interaction between cancer cells and white blood cells in an experimental flow system. Fluid dynamics, structural mechanics, six-degree-of-freedom motion control, and surface biochemistry analysis components are coupled in the context of adaptive octree-based grid generation. Analytical and numerical verification of the quasi-steady assumption for the fluid mechanics is presented. The capabilities of the technique are demonstrated by presenting several three-dimensional cell system simulations, including the collision/interaction between a cancer cell and an endothelium adherent polymorphonuclear leukocyte (PMN) cell in a shear flow.

AB - A method for the computation of low-Reynolds number dynamic blood cell systems is presented. The specific system of interest here is interaction between cancer cells and white blood cells in an experimental flow system. Fluid dynamics, structural mechanics, six-degree-of-freedom motion control, and surface biochemistry analysis components are coupled in the context of adaptive octree-based grid generation. Analytical and numerical verification of the quasi-steady assumption for the fluid mechanics is presented. The capabilities of the technique are demonstrated by presenting several three-dimensional cell system simulations, including the collision/interaction between a cancer cell and an endothelium adherent polymorphonuclear leukocyte (PMN) cell in a shear flow.

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JO - Journal of Fluids and Structures

JF - Journal of Fluids and Structures

IS - 5

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Coupled flow-structure-biochemistry simulations of dynamic systems of blood cells using an adaptive surface tracking method

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