TY - JOUR
T1 - Coupled motions in enzyme catalysis
AU - Nashine, Vishal C.
AU - Hammes-Schiffer, Sharon
AU - Benkovic, Stephen J.
PY - 2010/10
Y1 - 2010/10
N2 - Recently, the hypothesis that protein motions are involved in enzymatic turnover has gained significant attention. We review cases where there is evidence that protein motions are rate-limiting in the overall catalytic cycle and examine experimental and theoretical evidence for how such motions enhance the probability of sampling the transition state configurations relative to the ground state. The impact of tunneling, the possible role of vibrational coupling and the value of conformational chemical landscapes are also scrutinized.
AB - Recently, the hypothesis that protein motions are involved in enzymatic turnover has gained significant attention. We review cases where there is evidence that protein motions are rate-limiting in the overall catalytic cycle and examine experimental and theoretical evidence for how such motions enhance the probability of sampling the transition state configurations relative to the ground state. The impact of tunneling, the possible role of vibrational coupling and the value of conformational chemical landscapes are also scrutinized.
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U2 - 10.1016/j.cbpa.2010.07.020
DO - 10.1016/j.cbpa.2010.07.020
M3 - Review article
C2 - 20729130
AN - SCOPUS:77957750629
SN - 1367-5931
VL - 14
SP - 644
EP - 651
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
IS - 5
ER -