Coupled vesicle morphogenesis and domain organization

Changjin Huang; Hongyan Yuan; Sulin Zhang

doi:10.1063/1.3549176

Coupled vesicle morphogenesis and domain organization

Changjin Huang, Hongyan Yuan, Sulin Zhang

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Protein-enriched membrane domains with distinct biophysical properties have been thought as the basic organizing units of cellular membrane. Using particle dynamics simulations, here we study phase separation dynamics and domain formation in binary vesicles. Our simulations clearly show the intimate coupling between domain compositions, lateral domain organization, and vesicle shape transformation. Our simulation results provide insights into the essential role of membrane domains in the coordinated remodeling of cellular membranes and in protein and lipid sorting.

Original language	English (US)
Article number	043702
Journal	Applied Physics Letters
Volume	98
Issue number	4
DOIs	https://doi.org/10.1063/1.3549176
State	Published - Jan 24 2011

All Science Journal Classification (ASJC) codes

Physics and Astronomy (miscellaneous)

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10.1063/1.3549176

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title = "Coupled vesicle morphogenesis and domain organization",

abstract = "Protein-enriched membrane domains with distinct biophysical properties have been thought as the basic organizing units of cellular membrane. Using particle dynamics simulations, here we study phase separation dynamics and domain formation in binary vesicles. Our simulations clearly show the intimate coupling between domain compositions, lateral domain organization, and vesicle shape transformation. Our simulation results provide insights into the essential role of membrane domains in the coordinated remodeling of cellular membranes and in protein and lipid sorting.",

author = "Changjin Huang and Hongyan Yuan and Sulin Zhang",

note = "Funding Information: This work was supported by the National Science Foundation under Grant No. CMMI-0826841.",

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AU - Yuan, Hongyan

AU - Zhang, Sulin

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PY - 2011/1/24

Y1 - 2011/1/24

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AB - Protein-enriched membrane domains with distinct biophysical properties have been thought as the basic organizing units of cellular membrane. Using particle dynamics simulations, here we study phase separation dynamics and domain formation in binary vesicles. Our simulations clearly show the intimate coupling between domain compositions, lateral domain organization, and vesicle shape transformation. Our simulation results provide insights into the essential role of membrane domains in the coordinated remodeling of cellular membranes and in protein and lipid sorting.

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Coupled vesicle morphogenesis and domain organization

Abstract

All Science Journal Classification (ASJC) codes

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