TY - JOUR
T1 - Cracking the Code
T2 - Enhancing Molecular Tools for Progress in Nanobiotechnology
AU - Avila, Yelixza I.
AU - Rebolledo, Laura P.
AU - Skelly, Elizabeth
AU - de Freitas Saito, Renata
AU - Wei, Hui
AU - Lilley, David
AU - Stanley, Robin E.
AU - Hou, Ya Ming
AU - Yang, Haoyun
AU - Sztuba-Solinska, Joanna
AU - Chen, Shi Jie
AU - Dokholyan, Nikolay V.
AU - Tan, Cheemeng
AU - Li, S. Kevin
AU - He, Xiaoming
AU - Zhang, Xiaoting
AU - Miles, Wayne
AU - Franco, Elisa
AU - Binzel, Daniel W.
AU - Guo, Peixuan
AU - Afonin, Kirill A.
N1 - Publisher Copyright:
© 2024 The Authors. Published by American Chemical Society.
PY - 2024/6/17
Y1 - 2024/6/17
N2 - Nature continually refines its processes for optimal efficiency, especially within biological systems. This article explores the collaborative efforts of researchers worldwide, aiming to mimic nature’s efficiency by developing smarter and more effective nanoscale technologies and biomaterials. Recent advancements highlight progress and prospects in leveraging engineered nucleic acids and proteins for specific tasks, drawing inspiration from natural functions. The focus is developing improved methods for characterizing, understanding, and reprogramming these materials to perform user-defined functions, including personalized therapeutics, targeted drug delivery approaches, engineered scaffolds, and reconfigurable nanodevices. Contributions from academia, government agencies, biotech, and medical settings offer diverse perspectives, promising a comprehensive approach to broad nanobiotechnology objectives. Encompassing topics from mRNA vaccine design to programmable protein-based nanocomputing agents, this work provides insightful perspectives on the trajectory of nanobiotechnology toward a future of enhanced biomimicry and technological innovation.
AB - Nature continually refines its processes for optimal efficiency, especially within biological systems. This article explores the collaborative efforts of researchers worldwide, aiming to mimic nature’s efficiency by developing smarter and more effective nanoscale technologies and biomaterials. Recent advancements highlight progress and prospects in leveraging engineered nucleic acids and proteins for specific tasks, drawing inspiration from natural functions. The focus is developing improved methods for characterizing, understanding, and reprogramming these materials to perform user-defined functions, including personalized therapeutics, targeted drug delivery approaches, engineered scaffolds, and reconfigurable nanodevices. Contributions from academia, government agencies, biotech, and medical settings offer diverse perspectives, promising a comprehensive approach to broad nanobiotechnology objectives. Encompassing topics from mRNA vaccine design to programmable protein-based nanocomputing agents, this work provides insightful perspectives on the trajectory of nanobiotechnology toward a future of enhanced biomimicry and technological innovation.
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U2 - 10.1021/acsabm.4c00432
DO - 10.1021/acsabm.4c00432
M3 - Review article
C2 - 38833534
AN - SCOPUS:85195298647
SN - 2576-6422
VL - 7
SP - 3587
EP - 3604
JO - ACS Applied Bio Materials
JF - ACS Applied Bio Materials
IS - 6
ER -