CRISPR-based functional analysis of chicken IRF9 reveals distinct modulation of dsRNA stimulated innate immune pathways

Keyphrases

• Double-stranded RNA 100%
• Functional Analysis 100%
• IRF9 100%
• Chicken Interferon 100%
• Innate Immune Pathways 100%
• Palindromic Repeats 100%
• Chicken 50%
• Type I Interferon Response 20%
• Highly Effective 10%
• Interferon-α (IFN-α) 10%
• Transcriptional Activation 10%
• Genome Annotation 10%
• Innate Immune Response 10%
• Immune Response 10%
• Gene Set Enrichment Analysis 10%
• Immune System 10%
• Transcriptional Regulator 10%
• Gene Repertoire 10%
• Transcriptome 10%
• Transcriptional Modulation 10%
• Regulatory Role 10%
• Toll-like 10%
• Transcriptional Repression 10%
• Broiler 10%
• Immune-related Genes 10%
• Retinoic Acid-inducible Gene I (RIG-I) 10%
• Antiviral Genes 10%
• Mammalian Model 10%
• Interferon-stimulated Genes 10%
• Reference Genome 10%
• Type I Interferon Signaling 10%
• Interferon Regulatory Factor 7 (IRF7) 10%
• Functional Evidence 10%
• Evidence Classification 10%

Biochemistry, Genetics and Molecular Biology

• Double-Stranded RNA 100%
• Interferon Type I 40%
• Transactivation 10%
• Transcription Initiation 10%
• Immune Response 10%
• Innate Immunity 10%
• Tretinoin 10%
• Retinoic Acid 10%
• Toll-Like Receptor 10%
• Genome Annotation 10%
• Mammalian Model 10%
• Broiler 10%
• Interferon-Stimulated Gene 10%
• Transcriptome 10%
• Genome-Wide Analysis of Gene Expression 10%
• IRF7 10%
• Reference Genome 10%

Immunology and Microbiology

• Double-Stranded RNA 100%
• interferon 40%
• Innate Immune System 10%
• Immune Response 10%
• IRF7 10%
• Transcriptome 10%
• Transactivation 10%
• Transcription Initiation 10%
• Broiler 10%
• Interferon-Stimulated Gene 10%
• Immune System 10%
• Toll-Like Receptor 10%