Cross-linking of the DNA repair protein O⁶-alkylguanine DNA alkyltransferase to DNA in the presence of antitumor nitrogen mustards

Medicine & Life Sciences

• DNA alkyltransferase 100%
• Mechlorethamine 86%
• DNA Repair 57%
• DNA 34%
• Guanine 30%
• Proteins 22%
• Chlorambucil 21%
• High Pressure Liquid Chromatography 12%
• chlorambucil half mustard 12%
• human AGT protein 11%
• Catalytic Domain 9%
• Mustard Plant 7%
• Protein Hydrolysates 7%
• methylamine 7%
• Electrospray Ionization Mass Spectrometry 7%
• link protein 7%
• Alkylation 6%
• Melphalan 6%
• Oligodeoxyribonucleotides 6%
• CHO Cells 6%
• Nuclear Proteins 5%
• Point Mutation 5%
• Polyacrylamide Gel Electrophoresis 4%
• Cyclophosphamide 4%
• Acids 3%
• Amino Acids 3%
• Peptides 3%
• Pharmaceutical Preparations 2%
• Neoplasms 1%

Chemical Compounds

• Nitrogen Mustard 87%
• Antitumor 57%
• Chlorambucil 41%
• Mechlorethamine 37%
• Guanine 33%
• Protein 25%
• Ethyl 19%
• Melphalan 10%
• Cyclophosphamide 9%
• Protein Hydrolysate 8%
• Methylamine 7%
• SDS Polyacrylamide Gel Electrophoresis 7%
• Alkylation 5%
• Mutation 5%
• Acid 4%
• Peptide 3%
• Drug 3%