Cross-linking of the human DNA repair protein O⁶-alkylguanine DNA alkyltransferase to DNA in the presence of 1,2,3,4-diepoxybutane

Keyphrases

• DNA Repair Enzymes 100%
• O6-methylguanine-DNA Methyltransferase 100%
• Human DNA 100%
• Diepoxybutane 100%
• Electrospray Ionization Mass Spectrometry 27%
• MS Analysis 18%
• Amino Acid Residues 18%
• Cross-linked 18%
• DNA Interstrand Crosslinks 18%
• HPLC-ESI-MS 18%
• Amino Acids 9%
• Mass Spectrometry Analysis 9%
• Active Sites 9%
• Chemical Structure 9%
• Tryptic Peptides 9%
• Monoadducts 9%
• Alkyl 9%
• Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis (SDS-PAGE) 9%
• Cytotoxicity 9%
• Guanine 9%
• Strong Correlation 9%
• Oligodeoxynucleotide 9%
• Mutagenic Activity 9%
• Cytotoxic Activity 9%
• Binding Residues 9%
• Industrial Chemicals 9%
• Mass Shift 9%
• 2′-Deoxyguanosine 9%
• Repair Proteins 9%
• Synthetic Peptides 9%
• 1,3-Butadiene 9%
• Modified Proteins 9%
• Acceptor Site 9%
• Nucleophilic Site 9%
• DNA Alkylation 9%
• Covalently Cross-linked 9%
• Bifunctional Alkylating Agent 9%
• DNA-protein Crosslinks 9%
• Catalytic Cysteine Residue 9%
• 2,3-butanediol (2,3-BDO) 9%
• Bis-electrophiles 9%
• Butanediol 9%
• DNA Conjugation 9%
• Cellular Expression 9%
• Authentic Standards 9%
• Specific Amino Acids 9%
• Double-stranded 9%

Pharmacology, Toxicology and Pharmaceutical Science

• 6 O Alkylguanine DNA Alkyltransferase 100%
• Diepoxybutane 100%
• High Performance Liquid Chromatography 36%
• Electrospray Ionization 36%
• Amino Acid 27%
• Phosphorus 32 9%
• Polyacrylamide Gel Electrophoresis 9%
• Deoxyribonucleoprotein 9%
• Cysteine 9%
• 1,3-Butadiene 9%
• Oligodeoxynucleotide 9%
• Electrophile 9%
• Alanine 9%
• Alkylating Agent 9%
• Guanine 9%
• Deoxyguanosine 9%
• Synthetic Peptide 9%
• Industrial Chemical 9%
• Cytotoxicity 9%
• Butanediol 9%
• 2,3 Butanediol 9%
• Peptide 9%