Cross-sectional study of osteopenia with quantitative MRI imaging and bone densitometry

F. W. Wehrli, J. A. Hopkins, S. N. Hwang, Kwon Song Hee Kwon Song, P. J. Snyder, J. G. Haddad

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143 Scopus citations


PURPOSE: To evaluation the cancellous bone-induced intravoxel spin dephasing rate (R2') and its relationship to bone mineral density and marrow fat and to examine these parameters as predictors of vertebral fracture status. MATERIALS AND METHODS: R2' and R2, the rate constants for reversible and irreversible spin dephasing, and marrow fat fraction were measured in the lumbar vertebrae and proximal femur. One hundred thirty-nine subjects (mean age, 62.4 years ± 11.4 [SD]; 33 men, 106 women) had spinal dual-energy x-ray absorptiometric bone mineral density (BMD) T scores ranging from +3 to -5. R2', BMD, and bone marrow composition as determinants of vertebral fracture status were examined. RESULTS: Strongest single predictors of fracture status for BMD and R2' were the Ward triangle (r2 = 0.48) and trochanter (r2 = 0.37), respectively. Combined, the two parameters and sites increased fracture prediction (r2 = 0.62), whereas the combination of multiple BMD sites did not. Multivariate regression involving marrow fat fraction further improved fracture status prediction. R2' was correlated with BMD at all sites, although slopes differed by a factor of up to 2.5, which reflected differences in trabecular orientation relative to the static field. R2, the true transverse relaxation rate, was negatively correlated with marrow fat fraction. A non-age-related increase in marrow fat fraction in osteoporosis parallels earlier findings in animal models. CONCLUSION: Cancellous bone marrow R2' measured in the proximal femur provides information, which, with BMD, improves prediction of vertebral fracture status.

Original languageEnglish (US)
Pages (from-to)527-538
Number of pages12
Issue number2
StatePublished - 2000

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging


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