Abstract
The X-ray crystal structure of the transcription factor IIA (TFIIA) in complex with the TATA-box-binding protein (TBP) and TATA-element DNA is presented at 2.5 Å resolution. TFIIA is composed of a P-barrel and a four-helix bundle motif that together have a boot-like appearance. The β-barrel extends the TBP β-sheet and bridges over the DNA major groove immediately upstream of the TATA box. The four-helix bundle contributes substantially to the surface of the complex available for interaction with additional transcription factors.
Original language | English (US) |
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Pages (from-to) | 127-134 |
Number of pages | 8 |
Journal | Nature |
Volume | 381 |
Issue number | 6578 |
DOIs | |
State | Published - May 9 1996 |
All Science Journal Classification (ASJC) codes
- General