Crystal structure of a yeast TFIIA/TBP/DNA complex

Song Tan; Yvonne Hunziker; David F. Sargent; Timothy J. Richmond

doi:10.1038/381127a0

Crystal structure of a yeast TFIIA/TBP/DNA complex

Song Tan
, Yvonne Hunziker
, David F. Sargent
, Timothy J. Richmond

Research output: Contribution to journal › Article › peer-review

261 Scopus citations

Abstract

The X-ray crystal structure of the transcription factor IIA (TFIIA) in complex with the TATA-box-binding protein (TBP) and TATA-element DNA is presented at 2.5 Å resolution. TFIIA is composed of a P-barrel and a four-helix bundle motif that together have a boot-like appearance. The β-barrel extends the TBP β-sheet and bridges over the DNA major groove immediately upstream of the TATA box. The four-helix bundle contributes substantially to the surface of the complex available for interaction with additional transcription factors.

Original language	English (US)
Pages (from-to)	127-134
Number of pages	8
Journal	Nature
Volume	381
Issue number	6578
DOIs	https://doi.org/10.1038/381127a0
State	Published - May 9 1996

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title = "Crystal structure of a yeast TFIIA/TBP/DNA complex",

abstract = "The X-ray crystal structure of the transcription factor IIA (TFIIA) in complex with the TATA-box-binding protein (TBP) and TATA-element DNA is presented at 2.5 {\AA} resolution. TFIIA is composed of a P-barrel and a four-helix bundle motif that together have a boot-like appearance. The β-barrel extends the TBP β-sheet and bridges over the DNA major groove immediately upstream of the TATA box. The four-helix bundle contributes substantially to the surface of the complex available for interaction with additional transcription factors.",

author = "Song Tan and Yvonne Hunziker and Sargent, \{David F.\} and Richmond, \{Timothy J.\}",

year = "1996",

month = may,

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doi = "10.1038/381127a0",

language = "English (US)",

volume = "381",

pages = "127--134",

journal = "Nature",

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publisher = "Nature Research",

number = "6578",

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T1 - Crystal structure of a yeast TFIIA/TBP/DNA complex

AU - Tan, Song

AU - Hunziker, Yvonne

AU - Sargent, David F.

AU - Richmond, Timothy J.

PY - 1996/5/9

Y1 - 1996/5/9

N2 - The X-ray crystal structure of the transcription factor IIA (TFIIA) in complex with the TATA-box-binding protein (TBP) and TATA-element DNA is presented at 2.5 Å resolution. TFIIA is composed of a P-barrel and a four-helix bundle motif that together have a boot-like appearance. The β-barrel extends the TBP β-sheet and bridges over the DNA major groove immediately upstream of the TATA box. The four-helix bundle contributes substantially to the surface of the complex available for interaction with additional transcription factors.

AB - The X-ray crystal structure of the transcription factor IIA (TFIIA) in complex with the TATA-box-binding protein (TBP) and TATA-element DNA is presented at 2.5 Å resolution. TFIIA is composed of a P-barrel and a four-helix bundle motif that together have a boot-like appearance. The β-barrel extends the TBP β-sheet and bridges over the DNA major groove immediately upstream of the TATA box. The four-helix bundle contributes substantially to the surface of the complex available for interaction with additional transcription factors.

UR - https://www.scopus.com/pages/publications/0029870514

UR - https://www.scopus.com/pages/publications/0029870514#tab=citedBy

U2 - 10.1038/381127a0

DO - 10.1038/381127a0

M3 - Article

C2 - 8610010

AN - SCOPUS:0029870514

SN - 0028-0836

VL - 381

SP - 127

EP - 134

JO - Nature

JF - Nature

IS - 6578

ER -

Crystal structure of a yeast TFIIA/TBP/DNA complex

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