TY - JOUR
T1 - CsrB sRNA family
T2 - sequestration of RNA-binding regulatory proteins
AU - Babitzke, Paul
AU - Romeo, Tony
N1 - Funding Information:
The authors would like to thank Carol Baker and Elena Sineva for critical reading of the manuscript. This work was supported by grant GM059969 from the National Institutes of Health.
PY - 2007/4
Y1 - 2007/4
N2 - Noncoding regulatory RNA molecules, also known as small RNAs, participate in several bacterial regulatory networks. The central component of the carbon storage regulator (Csr) and the homologous repressor of secondary metabolites (Rsm) systems is an RNA binding protein (CsrA or RsmA) that regulates gene expression post-transcriptionally by affecting ribosome binding and/or mRNA stability. Members of the CsrB family of noncoding regulatory RNA molecules contain multiple CsrA binding sites and function as CsrA antagonists by sequestering this protein. Depending on the particular organism, the Csr (or Rsm) system participates in global regulatory circuits that control central carbon flux, the production of extracellular products, cell motility, biofilm formation, quorum sensing and/or pathogenesis.
AB - Noncoding regulatory RNA molecules, also known as small RNAs, participate in several bacterial regulatory networks. The central component of the carbon storage regulator (Csr) and the homologous repressor of secondary metabolites (Rsm) systems is an RNA binding protein (CsrA or RsmA) that regulates gene expression post-transcriptionally by affecting ribosome binding and/or mRNA stability. Members of the CsrB family of noncoding regulatory RNA molecules contain multiple CsrA binding sites and function as CsrA antagonists by sequestering this protein. Depending on the particular organism, the Csr (or Rsm) system participates in global regulatory circuits that control central carbon flux, the production of extracellular products, cell motility, biofilm formation, quorum sensing and/or pathogenesis.
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U2 - 10.1016/j.mib.2007.03.007
DO - 10.1016/j.mib.2007.03.007
M3 - Review article
C2 - 17383221
AN - SCOPUS:34247169597
SN - 1369-5274
VL - 10
SP - 156
EP - 163
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
IS - 2
ER -
