Abstract
Background: CT scan measures of emphysema and airway disease have been correlated with lung function in cohorts of subjects with a range of COPD severity. The contribution of CT scan-assessed airway disease to objective measures of lung function and respiratory symptoms such as dyspnea in severe emphysema is less clear. Methods: Using data from 338 subjects in the National Emphysema Treatment Trial (NETT) Genetics Ancillary Study, densitometric measures of emphysema using a threshold of -950 Hounsfield units (%LAA-950) and airway wall phenotypes of the wall thickness (WT) and the square root of wall area (SRWA) of a 10-mm luminal perimeter airway were calculated for each subject. Linear regression analysis was performed for outcome variables FEV 1 and percent predicted value of FEV1 with CT scan measures of emphysema and airway disease. Results: In univariate analysis, there were significant negative correlations between %LAA-950 and both the WT (r = -0.28, p = 0.0001) and SRWA (r = -0.19, p = 0.0008). Airway wall thickness was weakly but significantly correlated with postbronchodilator FEV1% predicted (R = -0.12, p = 0.02). Multivariate analysis showed significant associations between either WT or SRWA (β = -5.2, p = 0.009; β = -2.6, p = 0.008, respectively) and %LAA-950 (β = -10.6, p = 0.03) with the postbronchodilator FEV1% predicted. Male subjects exhibited significantly thicker airway wall phenotypes (p = 0.007 for WT and p = 0.0006 for SRWA). Conclusions: Airway disease and emphysema detected by CT scanning are inversely related in patients with severe COPD. Airway wall phenotypes were influenced by gender and associated with lung function in subjects with severe emphysema.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 396-404 |
| Number of pages | 9 |
| Journal | CHEST |
| Volume | 136 |
| Issue number | 2 |
| DOIs | |
| State | Published - Aug 1 2009 |
All Science Journal Classification (ASJC) codes
- Pulmonary and Respiratory Medicine
- Critical Care and Intensive Care Medicine
- Cardiology and Cardiovascular Medicine
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In: CHEST, Vol. 136, No. 2, 01.08.2009, p. 396-404.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - CT metrics of airway disease and emphysema in severe COPD
AU - Kim, Woo Jin
AU - Silverman, Edwin K.
AU - Hoffman, Eric
AU - Criner, Gerard J.
AU - Mosenifar, Zab
AU - Sciurba, Frank C.
AU - Make, Barry J.
AU - Carey, Vincent
AU - San José Estépar, Raúl
AU - Diaz, Alejandro
AU - Reilly, John J.
AU - Martinez, Fernando J.
AU - Washko, George R.
AU - Fishman, Alfred P.
AU - Bozzarello, Betsy Ann
AU - Al-Amin, Ameena
AU - Katz, Marcia
AU - Wheeler, Carolyn
AU - Baker, Elaine
AU - Barnard, Peter
AU - Cagle, Phil
AU - Carter, James
AU - Chatziioannou, Sophia
AU - Conejo-Gonzales, Karla
AU - Dubose, Kimberly
AU - Haddad, John
AU - Hicks, David
AU - Kleiman, Neal
AU - Milburn-Barnes, Mary
AU - Nguyen, Chinh
AU - Reardon, Michael
AU - Reeves-Viets, Joseph
AU - Sax, Steven
AU - Sharafkhaneh, Amir
AU - Wilson, Owen
AU - Young, Christine
AU - Espada, Rafael
AU - Butanda, Rose
AU - Ellisor, Minnie
AU - Fox, Pamela
AU - Hale, Katherine
AU - Hood, Everett
AU - Jahn, Amy
AU - Jhingran, Satish
AU - King, Karen
AU - Miller, Charles
AU - Nizami, Imran
AU - Officer, Todd
AU - Ricketts, Jeannie
AU - Rodarte, Joe
AU - Teague, Robert
AU - Williams, Kedren
AU - Reilly, John
AU - Sugarbaker, David
AU - Fanning, Carol
AU - Body, Simon
AU - Duffy, Sabine
AU - Formanek, Vladmir
AU - Fuhlbrigge, Anne
AU - Hartigan, Philip
AU - Hooper, Sarah
AU - Hunsaker, Andetta
AU - Jacobson, Francine
AU - Moy, Marilyn
AU - Peterson, Susan
AU - Russell, Roger
AU - Saunders, Diane
AU - Swanson, Scott
AU - McKenna, Rob
AU - Mohsenifar, Zab
AU - Geaga, Carol
AU - Biring, Manmohan
AU - Clark, Susan
AU - Cutler, Jennifer
AU - Frantz, Robert
AU - Julien, Peter
AU - Lewis, Michael
AU - Minkoff-Rau, Jennifer
AU - Yegyan, Valentina
AU - Joyner, Milton
AU - De-Camp, Malcolm
AU - Stoller, James
AU - Meli, Yvonne
AU - Apostolakis, John
AU - Atwell, Darryl
AU - Chapman, Jeffrey
AU - DeVilliers, Pierre
AU - Dweik, Raed
AU - Kraenzler, Erik
AU - Lann, Rosemary
AU - Kurokawa, Nancy
AU - Marlow, Scott
AU - McCarthy, Kevin
AU - McCreight, Priscilla
AU - Mehta, Atul
AU - Meziane, Moulay
AU - Minai, Omar
AU - Steiger, Mindi
AU - White, Kenneth
AU - Maurer, Janet
AU - Durr, Terri
AU - Hearn, Charles
AU - Lubell, Susan
AU - O'Donovan, Peter
AU - Schilz, Robert
AU - Ginsburg, Mark
AU - Thomashow, Byron
AU - Jellen, Patricia
AU - Austin, John
AU - Bartels, Matthew
AU - Berkmen, Yahya
AU - Berkoski, Patricia
AU - Brogan, Frances
AU - Chong, Amy
AU - DeMercado, Glenda
AU - DiMango, Angela
AU - Do, Sandy
AU - Kachulis, Bessie
AU - Khan, Arfa
AU - Mets, Berend
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AU - Pearson, Gregory
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AU - Shiau, Maria
AU - Simonelli, Paul
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AU - Tsang, Donna
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AU - Lawlor, Brian
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AU - Shearer, Sheila
AU - Smith, Jeanne
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AU - Steele, Mark
AU - Norten, Jennifer
AU - Utz, James
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AU - Mieras, Kathy
AU - Abel, Martin
AU - Allen, Mark
AU - Andrist, Deb
AU - Aughenbaugh, Gregory
AU - Bendel, Sharon
AU - Edell, Eric
AU - Edgar, Marlene
AU - Edwards, Bonnie
AU - Elliot, Beth
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AU - Gillespie, Delmar
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AU - Hart, June
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AU - Jenson, Nicole
AU - Kalra, Sanjay
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AU - Lamb, Jennifer
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AU - Swensen, Stephen
AU - Sykes, Anne Marie
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AU - Torres, Norman
AU - Hubmayr, Rolf
AU - Miller, Daniel
AU - Bartling, Sara
AU - Bradt, Kris
AU - Make, Barry
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AU - Dibbern, Phyllis
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AU - Quaife, Robert
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AU - Raymond, Cynthia
AU - Whalen-Price, Jane
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AU - Zamora, Martin
AU - Cherniack, Reuben
AU - Diaz, Philip
AU - Ross, Patrick
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AU - Rittinger, Mahasti
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AU - Carney, Kevin
AU - Chatila, Wissam
AU - Cordova, Francis
AU - D'Alonzo, Gilbert
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AU - Kirsch, Karen
AU - Kwak, Chul
AU - Lautensack, Kathy
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AU - Rising, Peter
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AU - Vance, Gwendolyn
AU - Boiselle, Phillip
AU - O'Brien, Gerald
AU - Ries, Andrew
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AU - Ramirez, Catherine
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AU - Friedman, Paul
AU - Harrell, James
AU - Johnson, Jeffery
AU - Kapelanski, David
AU - Kupferberg, David
AU - Larsen, Catherine
AU - Limberg, Trina
AU - Magliocca, Michael
AU - Papatheofanis, Frank J.
AU - Sassi-Dambron, Dawn
AU - Weeks, Melissa
AU - Krasna, Mark
AU - Fessler, Henry
AU - Moskowitz, Iris
AU - Gilbert, Timothy
AU - Orens, Jonathan
AU - Shade, David
AU - Siegelman, Stanley
AU - Silver, Kenneth
AU - Weir, Clarence
AU - White, Charles
AU - Martinez, Fernando
AU - Iannettoni, Mark
AU - Meldrum, Catherine
AU - Bria, William
AU - Campbell, Kelly
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AU - Flaherty, Kevin
AU - Gay, Steven
AU - Gill, Paramjit
AU - Kazanjian, Paul
AU - Kazerooni, Ella
AU - Knieper, Vivian
AU - Ojo, Tammy
AU - Poole, Lewis
AU - Quint, Leslie
AU - Rysso, Paul
AU - Sisson, Thomas
AU - True, Mercedes
AU - Woodcock, Brian
AU - Zaremba, Lori
AU - Kaiser, Larry
AU - Hansen-Flaschen, John
AU - Dempsey, Mary Louise
AU - Alavi, Abass
AU - Alcorn, Theresa
AU - Arcasoy, Selim
AU - Aronchick, Judith
AU - Aukberg, Stanley
AU - Benedict, Bryan
AU - Craemer, Susan
AU - Daniele, Ron
AU - Edelman, Jeffrey
AU - Gefter, Warren
AU - Kotler-Klein, Laura
AU - Kotloff, Robert
AU - Lipson, David
AU - Miller, Wallace
AU - O'Connell, Richard
AU - Opelman, Staci
AU - Palevsky, Harold
AU - Russell, William
AU - Sheaffer, Heather
AU - Simcox, Rodney
AU - Snedeker, Susanne
AU - Stone-Wynne, Jennifer
AU - Tino, Gregory
AU - Wahl, Peter
AU - Walter, James
AU - Ward, Patricia
AU - Zisman, David
AU - Mendez, James
AU - Wurster, Angela
AU - Luketich, James
AU - Witt, Colleen
AU - Ayres, Gerald
AU - Donahoe, Michael
AU - Fuhrman, Carl
AU - Hoffman, Robert
AU - Lacomis, Joan
AU - Sexton, Joan
AU - Slivka, William
AU - Strollo, Diane
AU - Sullivan, Erin
AU - Simon, Tomeka
AU - Wrona, Catherine
AU - Bauldoff, Gerene
AU - Brown, Manuel
AU - George, Elisabeth
AU - Keenan, Robert
AU - Kopp, Theodore
AU - Silfies, Laurie
AU - Benditt, Joshua
AU - Wood, Douglas
AU - Snyder, Margaret
AU - Anable, Kymberley
AU - Battaglia, Nancy
AU - Boitano, Louie
AU - Bowdle, Andrew
AU - Chan, Leighton
AU - Chwalik, Cindy
AU - Culver, Bruce
AU - Gillespy, Thurman
AU - Godwin, David
AU - Hoffman, Jeanne
AU - Ibrahim, Andra
AU - Lockhart, Diane
AU - Marglin, Stephen
AU - Martay, Kenneth
AU - McDowell, Patricia
AU - Oxorn, Donald
AU - Roessler, Liz
AU - Toshima, Michelle
AU - Golden, Susan
AU - Bosco, Lynn
AU - Chiang, Yen Pin
AU - Clancy, Carolyn
AU - Handelsman, Harry
AU - Berkowitz, Steven M.
AU - Carino, Tanisha
AU - Chin, Joe
AU - Baldwin, Jo Anna
AU - McVearry, Karen
AU - Norris, Anthony
AU - Shirey, Sarah
AU - Sikora, Claudette
AU - Sheingold, Steven
AU - Piantadosi, Steven
AU - Tonascia, James
AU - Belt, Patricia
AU - Blackford, Amanda
AU - Collins, Karen
AU - Collison, Betty
AU - Colvin, Ryan
AU - Dodge, John
AU - Donithan, Michele
AU - Edmonds, Vera
AU - Foster, Gregory L.
AU - Fuller, Julie
AU - Harle, Judith
AU - Jackson, Rosetta
AU - Lee, Shing
AU - Levine, Charlene
AU - Livingston, Hope
AU - Meinert, Jill
AU - Meyers, Jennifer
AU - Nowakowski, Deborah
AU - Owens, Kapreena
AU - Qi, Shangqian
AU - Smith, Michael
AU - Simon, Brett
AU - Smith, Paul
AU - Sternberg, Alice
AU - Van Natta, Mark
AU - Wilson, Laura
AU - Wise, Robert
AU - Kaplan, Robert M.
AU - Schwartz, J. Sanford
AU - Fahs, Marianne C.
AU - Fendrick, A. Mark
AU - Moskowitz, Alan J.
AU - Pathak, Dev
AU - Ramsey, Scott
AU - Shroyer, A. Laurie
AU - Wagner, Judith
AU - Yusen, Roger
AU - Etzioni, Ruth
AU - Sullivan, Sean
AU - Schroeder, Thomas
AU - Kreizenbeck, Karma
AU - Berry, Kristin
AU - Howlader, Nadia
AU - Cook-Granroth, Janice
AU - Delsing, Angela
AU - Guo, Junfeng
AU - McLennan, Geoffrey
AU - Mullan, Brian
AU - Piker, Chris
AU - Reinhardt, Joseph
AU - Wood, Blake
AU - Sieren, Jered
AU - Stanford, William
AU - Waldhausen, John A.
AU - Bernard, Gordon
AU - DeMets, David
AU - Ferguson, Mark
AU - Hoover, Eddie
AU - Levine, Robert
AU - Mahler, Donald
AU - McSweeny, A. John
AU - Wiener-Kronish, Jeanine
AU - Williams, Dale
AU - Younes, Magdy
AU - Soltoff, Charles
AU - Weinmann, Gail
AU - Deshler, Joanne
AU - Follmann, Dean
AU - Kiley, James
AU - Wu, Margaret
N1 - Funding Information: Funding/Support: This research was funded by National Institutes of Health [grant No. 1K23HL089353-01A1] and a grant from the Parker B. Francis Foundation. The NETT is supported by contracts with the National Heart, Lung, and Blood Institute [grants No. N01HR76101, N01HR76102, N01HR76103, N01HR76104, N01HR76105, N01HR76106, N01HR76107, N01HR76108, N01HR76109, N01HR76110, N01HR76111, N01HR76112, N01HR76113, N01HR76114, N01HR76115, N01HR76116, N01HR76118, and N01HR76119], the Centers for Medicare and Medicaid Services, and the Agency for Healthcare Research and Quality.
PY - 2009/8/1
Y1 - 2009/8/1
N2 - Background: CT scan measures of emphysema and airway disease have been correlated with lung function in cohorts of subjects with a range of COPD severity. The contribution of CT scan-assessed airway disease to objective measures of lung function and respiratory symptoms such as dyspnea in severe emphysema is less clear. Methods: Using data from 338 subjects in the National Emphysema Treatment Trial (NETT) Genetics Ancillary Study, densitometric measures of emphysema using a threshold of -950 Hounsfield units (%LAA-950) and airway wall phenotypes of the wall thickness (WT) and the square root of wall area (SRWA) of a 10-mm luminal perimeter airway were calculated for each subject. Linear regression analysis was performed for outcome variables FEV 1 and percent predicted value of FEV1 with CT scan measures of emphysema and airway disease. Results: In univariate analysis, there were significant negative correlations between %LAA-950 and both the WT (r = -0.28, p = 0.0001) and SRWA (r = -0.19, p = 0.0008). Airway wall thickness was weakly but significantly correlated with postbronchodilator FEV1% predicted (R = -0.12, p = 0.02). Multivariate analysis showed significant associations between either WT or SRWA (β = -5.2, p = 0.009; β = -2.6, p = 0.008, respectively) and %LAA-950 (β = -10.6, p = 0.03) with the postbronchodilator FEV1% predicted. Male subjects exhibited significantly thicker airway wall phenotypes (p = 0.007 for WT and p = 0.0006 for SRWA). Conclusions: Airway disease and emphysema detected by CT scanning are inversely related in patients with severe COPD. Airway wall phenotypes were influenced by gender and associated with lung function in subjects with severe emphysema.
AB - Background: CT scan measures of emphysema and airway disease have been correlated with lung function in cohorts of subjects with a range of COPD severity. The contribution of CT scan-assessed airway disease to objective measures of lung function and respiratory symptoms such as dyspnea in severe emphysema is less clear. Methods: Using data from 338 subjects in the National Emphysema Treatment Trial (NETT) Genetics Ancillary Study, densitometric measures of emphysema using a threshold of -950 Hounsfield units (%LAA-950) and airway wall phenotypes of the wall thickness (WT) and the square root of wall area (SRWA) of a 10-mm luminal perimeter airway were calculated for each subject. Linear regression analysis was performed for outcome variables FEV 1 and percent predicted value of FEV1 with CT scan measures of emphysema and airway disease. Results: In univariate analysis, there were significant negative correlations between %LAA-950 and both the WT (r = -0.28, p = 0.0001) and SRWA (r = -0.19, p = 0.0008). Airway wall thickness was weakly but significantly correlated with postbronchodilator FEV1% predicted (R = -0.12, p = 0.02). Multivariate analysis showed significant associations between either WT or SRWA (β = -5.2, p = 0.009; β = -2.6, p = 0.008, respectively) and %LAA-950 (β = -10.6, p = 0.03) with the postbronchodilator FEV1% predicted. Male subjects exhibited significantly thicker airway wall phenotypes (p = 0.007 for WT and p = 0.0006 for SRWA). Conclusions: Airway disease and emphysema detected by CT scanning are inversely related in patients with severe COPD. Airway wall phenotypes were influenced by gender and associated with lung function in subjects with severe emphysema.
UR - http://www.scopus.com/inward/record.url?scp=68849086909&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68849086909&partnerID=8YFLogxK
U2 - 10.1378/chest.08-2858
DO - 10.1378/chest.08-2858
M3 - Article
C2 - 19411295
AN - SCOPUS:68849086909
SN - 0012-3692
VL - 136
SP - 396
EP - 404
JO - CHEST
JF - CHEST
IS - 2
ER -