TY - JOUR
T1 - CT screening for lung cancer
T2 - Diagnoses resulting from the New York Early Lung Cancer Action Project
AU - Henschke, Claudia I.
AU - Yankelevitz, David F.
AU - McCauley, Dorothy I.
AU - Rifkin, Matthew
AU - Fiore, Edward S.
AU - Austin, John H.M.
AU - Pearson, Gregory D.N.
AU - Shiau, Maria C.
AU - Kopel, Samuel
AU - Klippenstein, Donald
AU - Litwin, Alan
AU - Loud, Peter A.
AU - Kohman, Leslie J.
AU - Scalzetti, Ernest M.
AU - Khan, Arfa
AU - Shah, Rakesh
AU - Mendelson, David S.
AU - Heelan, Robert T.
AU - Ginsberg, Michelle S.
AU - Matalon, Terence A.S.
AU - Wiernik, Peter H.
AU - Altorki, Nasser
AU - Farooqi, Ali
AU - Faustini, Yolanda
AU - Libby, Daniel M.
AU - Miettinen, Olli S.
AU - Ostroff, Jamie
AU - Pasmantier, Mark W.
AU - Reeves, Anthony P.
AU - Smith, James P.
AU - Vazquez, Madeline F.
AU - Yip, Rowena
AU - Agnello, Kimberly K.
AU - Kramer, Arin L.
AU - Hess, Jennifer M.
AU - Carter, Darryl
AU - Brambilla, Elizabeth
AU - Gazdar, Adi
AU - Noguchi, Masayuki
AU - Travis, William D.
PY - 2007/4
Y1 - 2007/4
N2 - Purpose: To evaluate prospectively the diagnostic performance of the New York Early Lung Cancer Action Project (NY-ELCAP) regimen in the diagnosis of early lung cancer at baseline and annual repeat computed tomographic (CT) screenings. Materials and Methods: Informed consent and institutional review board approval were obtained for this HIPAA-compliant study of baseline and annual repeat low-dose CT screening performed with a common regimen in asymptomatic individuals at 12 institutions in New York State. All 6295 participants were aged 60 years or older, had smoked for at least 10 pack-years, had no prior cancer, had not undergone chest CT in the previous 3 years, and were medically fit to undergo thoracic surgery. Median age was 66 years, and median smoking history was 40 pack-years. The proportion (and 95% exact confidence intervals [Cls]) of subjects with a positive result, as determined by using nodule size; the diagnoses of lung cancer resulting from subsequent work-up; and the distribution by cancer stage and cell type were determined. When relevant, 95% CIs for the proportions were calculated. Results: Initial CT imaging led to recommendations for further work-up in 14.4% (95% CI: 13.5%, 15.3%) of the 6295 baseline screenings and 6.0% (95% CI: 5.1%, 6.6%) of the 6014 annual repeat screenings. Of 101 patients in whom the diagnosis of lung cancer resulted from baseline screening and three in whom a diagnosis of lung cancer was prompted by symptoms prior to the first scheduled repeat screening, 95 (91.3%) had no clinical evidence of metastases. Of the 20 patients whom the diagnosis of lung cancer resulted from annual repeat screening, 17 (85%) showed no evidence of metastases. Of the 134 recommended biopsies, 125 (93.3%) resulted in diagnosis of lung cancer or another malignancy, while none of the 24 biopsies performed outside of the recommendation of the regimen resulted in diagnosis of lung cancer. Conclusions: The NY-ELCAP regimen of screening revealed that annual CT screening for lung cancer, resulted in identification of a high proportion of patients with early-stage disease.
AB - Purpose: To evaluate prospectively the diagnostic performance of the New York Early Lung Cancer Action Project (NY-ELCAP) regimen in the diagnosis of early lung cancer at baseline and annual repeat computed tomographic (CT) screenings. Materials and Methods: Informed consent and institutional review board approval were obtained for this HIPAA-compliant study of baseline and annual repeat low-dose CT screening performed with a common regimen in asymptomatic individuals at 12 institutions in New York State. All 6295 participants were aged 60 years or older, had smoked for at least 10 pack-years, had no prior cancer, had not undergone chest CT in the previous 3 years, and were medically fit to undergo thoracic surgery. Median age was 66 years, and median smoking history was 40 pack-years. The proportion (and 95% exact confidence intervals [Cls]) of subjects with a positive result, as determined by using nodule size; the diagnoses of lung cancer resulting from subsequent work-up; and the distribution by cancer stage and cell type were determined. When relevant, 95% CIs for the proportions were calculated. Results: Initial CT imaging led to recommendations for further work-up in 14.4% (95% CI: 13.5%, 15.3%) of the 6295 baseline screenings and 6.0% (95% CI: 5.1%, 6.6%) of the 6014 annual repeat screenings. Of 101 patients in whom the diagnosis of lung cancer resulted from baseline screening and three in whom a diagnosis of lung cancer was prompted by symptoms prior to the first scheduled repeat screening, 95 (91.3%) had no clinical evidence of metastases. Of the 20 patients whom the diagnosis of lung cancer resulted from annual repeat screening, 17 (85%) showed no evidence of metastases. Of the 134 recommended biopsies, 125 (93.3%) resulted in diagnosis of lung cancer or another malignancy, while none of the 24 biopsies performed outside of the recommendation of the regimen resulted in diagnosis of lung cancer. Conclusions: The NY-ELCAP regimen of screening revealed that annual CT screening for lung cancer, resulted in identification of a high proportion of patients with early-stage disease.
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U2 - 10.1148/radiol.2431060467
DO - 10.1148/radiol.2431060467
M3 - Article
C2 - 17392256
AN - SCOPUS:34147215960
SN - 0033-8419
VL - 243
SP - 239
EP - 249
JO - Radiology
JF - Radiology
IS - 1
ER -