Culture-proven endogenous endophthalmitis: Clinical features and visual acuity outcomes

Vivian Schiedler, Ingrid U. Scott, Harry W. Flynn, Janet L. Davis, Matthew S. Benz, Darlene Miller

Research output: Contribution to journalArticlepeer-review

217 Scopus citations


Purpose To investigate clinical features and visual acuity outcomes associated with endogenous endophthalmitis. Design Retrospective, observational case series. Methods Twenty-one eyes of 21 patients treated at Bascom Palmer Eye Institute for culture-proven endogenous endophthalmitis between 1996 and 2002 were reviewed. Results Patients were followed a mean of 3 months (range, 1 to 12 months). Fungal isolates occurred in 13 eyes (62%), gram-positive isolates in 7 (33%), and gram-negative isolates in 1 (5%). Twelve patients (57%) were hospitalized at the time of diagnosis and 6 patients (29%) died within 2 months of diagnosis. Initial treatment included tap and injection of intravitreal medication in 10 eyes (48%) and pars plana vitrectomy with injection of intravitreal medication in 11 eyes (52%). Final visual outcomes were obtainable for 18 eyes (two patients died within 10 days of diagnosis, and one patient was lost to follow-up). Eight (44%) of these 18 eyes achieved a visual acuity of 20/400 or better and 10 (56%) of 18 eyes achieved a visual acuity worse than 20/400, including 3 that were either enucleated or eviscerated. Three eyes with Aspergillus endophthalmitis had worse visual outcomes than eyes with either Candida (P = .036) or bacterial endophthalmitis (P = .024). Conclusions Compared with published series of postoperative or post-traumatic endophthalmitis, patients with endogenous endophthalmitis are more likely to have fungal isolates with a predominance of Candida albicans. Endogenous endophthalmitis is generally associated with high mortality and poor visual acuity outcomes, particularly when caused by more virulent species such as Aspergillus.

Original languageEnglish (US)
Pages (from-to)725-731
Number of pages7
JournalAmerican Journal of Ophthalmology
Issue number4
StatePublished - Apr 2004

All Science Journal Classification (ASJC) codes

  • Ophthalmology


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