Curcumin suppresses activation of NF-kappaB and AP-1 induced by phorbol ester in cultured human promyelocytic leukemia cells.

Seong Su Han, Young Sam Keum, Hyo Joung Seo, Young Joon Surh

Research output: Contribution to journalArticlepeer-review

179 Scopus citations

Abstract

Many components that are derived from medicinal or dietary plants possess potential chemopreventive properties. Curcumin, a yellow coloring agent from turmeric (Curcuma longa Linn, Zingiberaceae), possesses strong antimutagenic and anticarcinogenic activities. In this study, we have found that curcumin inhibits the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced nuclear factor kB (NF-kappaB) activation by preventing the degradation of the inhibitory protein IkBalpa; and the subsequent translocation of the p65 subunit in cultured human promyelocytic leukemia (HL-60) cells. Alternatively, curcumin repressed the TPA-induced activation of NF-kappaB through direct interruption of the binding of NF-kappaB to its consensus DNA sequences. Likewise, the TPA-induced DNA binding of the activator protein-1 (AP-1) was inhibited by curcumin pretreatment.

Original languageEnglish (US)
Pages (from-to)337-342
Number of pages6
JournalJournal of Biochemistry and Molecular Biology
Volume35
Issue number3
StatePublished - May 31 2002

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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