TY - JOUR
T1 - Current Treatment Options for Peripheral Nerve Hyperexcitability Syndromes
AU - Elangovan, Cheran
AU - Morawo, Adeolu
AU - Ahmed, Aiesha
N1 - Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Purpose of review: Peripheral nerve hyperexcitability (PNH) syndromes are divided into primary and secondary groups based on the presence or absence of demonstrable peripheral nerve disease. In this review, we systematically evaluate the evidence for current therapies and supportive managements based on autoimmune, paraneoplastic, and genetic components in pathophysiology reported in the literature. Recent findings: Current therapy options are based on symptomatic management as well as focusing the underlying immune/genetic/paraneoplastic pathology by immunosuppressants, chemotherapy, and surgery. Summary: Further research is desired to provide treatment options geared specifically towards addressing PNH. Supportive care can also be an area for future research.
AB - Purpose of review: Peripheral nerve hyperexcitability (PNH) syndromes are divided into primary and secondary groups based on the presence or absence of demonstrable peripheral nerve disease. In this review, we systematically evaluate the evidence for current therapies and supportive managements based on autoimmune, paraneoplastic, and genetic components in pathophysiology reported in the literature. Recent findings: Current therapy options are based on symptomatic management as well as focusing the underlying immune/genetic/paraneoplastic pathology by immunosuppressants, chemotherapy, and surgery. Summary: Further research is desired to provide treatment options geared specifically towards addressing PNH. Supportive care can also be an area for future research.
UR - http://www.scopus.com/inward/record.url?scp=85047878200&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85047878200&partnerID=8YFLogxK
U2 - 10.1007/s11940-018-0510-9
DO - 10.1007/s11940-018-0510-9
M3 - Review article
C2 - 29808385
AN - SCOPUS:85047878200
SN - 1092-8480
VL - 20
JO - Current Treatment Options in Neurology
JF - Current Treatment Options in Neurology
IS - 7
M1 - 23
ER -