Current understanding of the genetic diversity of Mycobacterium avium subsp. paratuberculosis

Alifiya S. Motiwala; Lingling Li; Vivek Kapur; Srinand Sreevatsan

doi:10.1016/j.micinf.2005.12.003

Current understanding of the genetic diversity of Mycobacterium avium subsp. paratuberculosis

Alifiya S. Motiwala, Lingling Li, Vivek Kapur, Srinand Sreevatsan

Research output: Contribution to journal › Short survey › peer-review

62 Scopus citations

Abstract

Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of Johne's disease (or paratuberculosis). Paratuberculosis is a chronic gastroenteritis mainly affecting cattle, sheep and other ruminants. MAP is also of concern due to the heretofore unresolved issue of its possible role in Crohn's disease in humans. We present here a review of MAP (i) mobile genetic elements; (ii) repetitive elements; (iii) single nucleotide polymorphisms; and (iv) whole-genome comparisons to study the molecular epidemiology of MAP. A summary of the findings to date is presented, and the discriminatory power, advantage and disadvantages of each of the methods are compared and discussed.

Original language	English (US)
Pages (from-to)	1406-1418
Number of pages	13
Journal	Microbes and Infection
Volume	8
Issue number	5
DOIs	https://doi.org/10.1016/j.micinf.2005.12.003
State	Published - Apr 2006

All Science Journal Classification (ASJC) codes

Microbiology
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.micinf.2005.12.003

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title = "Current understanding of the genetic diversity of Mycobacterium avium subsp. paratuberculosis",

abstract = "Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of Johne's disease (or paratuberculosis). Paratuberculosis is a chronic gastroenteritis mainly affecting cattle, sheep and other ruminants. MAP is also of concern due to the heretofore unresolved issue of its possible role in Crohn's disease in humans. We present here a review of MAP (i) mobile genetic elements; (ii) repetitive elements; (iii) single nucleotide polymorphisms; and (iv) whole-genome comparisons to study the molecular epidemiology of MAP. A summary of the findings to date is presented, and the discriminatory power, advantage and disadvantages of each of the methods are compared and discussed.",

author = "Motiwala, {Alifiya S.} and Lingling Li and Vivek Kapur and Srinand Sreevatsan",

note = "Funding Information: This work was supported by state and federal funds appropriated to the Ohio Agricultural Research and Development Center (OARDC). Research in SS laboratory is supported through OARDC Competitive Research Enhancement Grants and the Johne's disease integrated program grant (USDA-NRICAP).",

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AU - Motiwala, Alifiya S.

AU - Li, Lingling

AU - Kapur, Vivek

AU - Sreevatsan, Srinand

N1 - Funding Information: This work was supported by state and federal funds appropriated to the Ohio Agricultural Research and Development Center (OARDC). Research in SS laboratory is supported through OARDC Competitive Research Enhancement Grants and the Johne's disease integrated program grant (USDA-NRICAP).

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N2 - Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of Johne's disease (or paratuberculosis). Paratuberculosis is a chronic gastroenteritis mainly affecting cattle, sheep and other ruminants. MAP is also of concern due to the heretofore unresolved issue of its possible role in Crohn's disease in humans. We present here a review of MAP (i) mobile genetic elements; (ii) repetitive elements; (iii) single nucleotide polymorphisms; and (iv) whole-genome comparisons to study the molecular epidemiology of MAP. A summary of the findings to date is presented, and the discriminatory power, advantage and disadvantages of each of the methods are compared and discussed.

AB - Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of Johne's disease (or paratuberculosis). Paratuberculosis is a chronic gastroenteritis mainly affecting cattle, sheep and other ruminants. MAP is also of concern due to the heretofore unresolved issue of its possible role in Crohn's disease in humans. We present here a review of MAP (i) mobile genetic elements; (ii) repetitive elements; (iii) single nucleotide polymorphisms; and (iv) whole-genome comparisons to study the molecular epidemiology of MAP. A summary of the findings to date is presented, and the discriminatory power, advantage and disadvantages of each of the methods are compared and discussed.

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JO - Microbes and Infection

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Current understanding of the genetic diversity of Mycobacterium avium subsp. paratuberculosis

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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