Cushing's syndrome due to adrenal adenoma with persistent diurnal cortisol secretory rhythm

Nancy J. Olsen; Victor S. Fang; Leslie J. DeGroot

doi:10.1016/0026-0495(78)90007-0

Cushing's syndrome due to adrenal adenoma with persistent diurnal cortisol secretory rhythm

Nancy J. Olsen, Victor S. Fang, Leslie J. DeGroot

Research output: Contribution to journal › Article › peer-review

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Abstract

A 41-yr-old female with presumed Cushing's syndrome was found to have a diurnal cortisol rhythm characterized by low values at 8:00 a.m. and consistently high values at 4:00 p.m. and midnight. Hourly sampling of plasma cortisol over 24 hr confirmed this rhythm, as did measurement of urinary free cortisols in samples collected every 6 hr over 24 hr. Hypercortisolemia was not suppressed by 2 mg of dexamethasone given every 6 hr for 24 hr. the adrenal tissue was responsive to ACTH. lodocholesterol scanning revealed unilateral activity, and the patient's syndrome was cured by resection of an adrenal adenoma. In this patient a diurnal cortisol secretory pattern was present due to the secretory activity of the adenoma. The cause of the abnormal but persistent diurnal pattern is unknown.

Original language	English (US)
Pages (from-to)	695-700
Number of pages	6
Journal	Metabolism
Volume	27
Issue number	6
DOIs	https://doi.org/10.1016/0026-0495(78)90007-0
State	Published - Jun 1978

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0026-0495(78)90007-0

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@article{6be289aa6827483e83d2e1526ceb9fd8,

title = "Cushing's syndrome due to adrenal adenoma with persistent diurnal cortisol secretory rhythm",

abstract = "A 41-yr-old female with presumed Cushing's syndrome was found to have a diurnal cortisol rhythm characterized by low values at 8:00 a.m. and consistently high values at 4:00 p.m. and midnight. Hourly sampling of plasma cortisol over 24 hr confirmed this rhythm, as did measurement of urinary free cortisols in samples collected every 6 hr over 24 hr. Hypercortisolemia was not suppressed by 2 mg of dexamethasone given every 6 hr for 24 hr. the adrenal tissue was responsive to ACTH. lodocholesterol scanning revealed unilateral activity, and the patient's syndrome was cured by resection of an adrenal adenoma. In this patient a diurnal cortisol secretory pattern was present due to the secretory activity of the adenoma. The cause of the abnormal but persistent diurnal pattern is unknown.",

author = "Olsen, {Nancy J.} and Fang, {Victor S.} and DeGroot, {Leslie J.}",

note = "Funding Information: From the Thyroid Study Unit, Department of Medicine. University of Chicago, Chicago, Ill. Received for publication June 27, 1977. Supported in part by USPHS Grants A M-I 3377 and FR-55. Address reprint requests to Leslie J. DeGroot, M.D., University of Chicago, Thyroid Study Unit, 950 East 59th St., Box 138, Chicago, Ill. 60637. 0 I978 by Grune & Stratton, Inc. 0026-0495/78/270&0@7$01.00/0",

year = "1978",

month = jun,

doi = "10.1016/0026-0495(78)90007-0",

language = "English (US)",

volume = "27",

pages = "695--700",

journal = "Metabolism",

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publisher = "W.B. Saunders Ltd",

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T1 - Cushing's syndrome due to adrenal adenoma with persistent diurnal cortisol secretory rhythm

AU - Olsen, Nancy J.

AU - Fang, Victor S.

AU - DeGroot, Leslie J.

N1 - Funding Information: From the Thyroid Study Unit, Department of Medicine. University of Chicago, Chicago, Ill. Received for publication June 27, 1977. Supported in part by USPHS Grants A M-I 3377 and FR-55. Address reprint requests to Leslie J. DeGroot, M.D., University of Chicago, Thyroid Study Unit, 950 East 59th St., Box 138, Chicago, Ill. 60637. 0 I978 by Grune & Stratton, Inc. 0026-0495/78/270&0@7$01.00/0

PY - 1978/6

Y1 - 1978/6

N2 - A 41-yr-old female with presumed Cushing's syndrome was found to have a diurnal cortisol rhythm characterized by low values at 8:00 a.m. and consistently high values at 4:00 p.m. and midnight. Hourly sampling of plasma cortisol over 24 hr confirmed this rhythm, as did measurement of urinary free cortisols in samples collected every 6 hr over 24 hr. Hypercortisolemia was not suppressed by 2 mg of dexamethasone given every 6 hr for 24 hr. the adrenal tissue was responsive to ACTH. lodocholesterol scanning revealed unilateral activity, and the patient's syndrome was cured by resection of an adrenal adenoma. In this patient a diurnal cortisol secretory pattern was present due to the secretory activity of the adenoma. The cause of the abnormal but persistent diurnal pattern is unknown.

AB - A 41-yr-old female with presumed Cushing's syndrome was found to have a diurnal cortisol rhythm characterized by low values at 8:00 a.m. and consistently high values at 4:00 p.m. and midnight. Hourly sampling of plasma cortisol over 24 hr confirmed this rhythm, as did measurement of urinary free cortisols in samples collected every 6 hr over 24 hr. Hypercortisolemia was not suppressed by 2 mg of dexamethasone given every 6 hr for 24 hr. the adrenal tissue was responsive to ACTH. lodocholesterol scanning revealed unilateral activity, and the patient's syndrome was cured by resection of an adrenal adenoma. In this patient a diurnal cortisol secretory pattern was present due to the secretory activity of the adenoma. The cause of the abnormal but persistent diurnal pattern is unknown.

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AN - SCOPUS:0018103060

SN - 0026-0495

VL - 27

SP - 695

EP - 700

JO - Metabolism

JF - Metabolism

IS - 6

ER -

Cushing's syndrome due to adrenal adenoma with persistent diurnal cortisol secretory rhythm

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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