TY - JOUR
T1 - Cutting edge
T2 - Intrinsic programming of thymic γδT cells for specific peripheral tissue localization
AU - Jin, Yan
AU - Xia, Mingcan
AU - Saylor, Christina M.
AU - Narayan, Kavitha
AU - Kang, Joonsoo
AU - Wiest, David L.
AU - Wang, Yanming
AU - Xiong, Na
PY - 2010/12/15
Y1 - 2010/12/15
N2 - Various innate-like T cell subsets preferentially reside in specific epithelial tissues as the first line of defense. However, mechanisms regulating their tissue-specific development are poorly understood. Using the prototypical skin intraepithelial γδT cells (sIELs) as a model, we show in this study that a TCR-mediated selection plays an important role in promoting acquisition of a specific skin-homing property by fetal thymic sIEL precursors for their epidermal location, and the skinhoming potential is intrinsically programmed even before the selection. In addition, once localized in the skin, the sIEL precursors develop into sIELs without the requirement of further TCR-ligand interaction. These studies reveal that development of the tissuespecific lymphocytes is a hard-wired process that targets them to specific tissues for proper functions.
AB - Various innate-like T cell subsets preferentially reside in specific epithelial tissues as the first line of defense. However, mechanisms regulating their tissue-specific development are poorly understood. Using the prototypical skin intraepithelial γδT cells (sIELs) as a model, we show in this study that a TCR-mediated selection plays an important role in promoting acquisition of a specific skin-homing property by fetal thymic sIEL precursors for their epidermal location, and the skinhoming potential is intrinsically programmed even before the selection. In addition, once localized in the skin, the sIEL precursors develop into sIELs without the requirement of further TCR-ligand interaction. These studies reveal that development of the tissuespecific lymphocytes is a hard-wired process that targets them to specific tissues for proper functions.
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U2 - 10.4049/jimmunol.1002781
DO - 10.4049/jimmunol.1002781
M3 - Article
C2 - 21068400
AN - SCOPUS:78650657574
SN - 0022-1767
VL - 185
SP - 7156
EP - 7160
JO - Journal of Immunology
JF - Journal of Immunology
IS - 12
ER -