Cyclic nucleotide gated channels as regulators of CNS development and plasticity

Frank Zufall, Gordon M. Shepherd, Colin J. Barnstable

Research output: Contribution to journalArticlepeer-review

100 Scopus citations


Cyclic nucleotide gated (CNG) cation channels are critical for signal transduction in vertebrate visual and olfactory systems. Members of the CNG channel gene family have now been cloned from a number of species, from Caenorhabditis elegans to humans. An important advance has been the discovery that CNG channels are present in many neurons of the mammalian brain. CNG channels act as molecular links between G-protein-coupled cascades, Ca2+-signalling systems, and gaseous messenger pathways. Perhaps most striking are recent data implicating CNG channels in both developmental and synaptic plasticity.

Original languageEnglish (US)
Pages (from-to)404-412
Number of pages9
JournalCurrent Opinion in Neurobiology
Issue number3
StatePublished - Jun 1997

All Science Journal Classification (ASJC) codes

  • General Neuroscience


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