Abstract
As a complement to Pd(0)-catalyzed cyclizations, seven Pd(II)-catalyzed cyclization strategies are reported. α,ω-Diynes are selectively hydroborated to bis(boronate esters), which cyclize under Pd(II)-catalysis producing a diverse array of small, medium, and macrocyclic polyenes with controlled E,E, Z,Z, or E,Z stereochemistry. Various functional groups are tolerated including aryl bromides, and applications are illustrated.
Original language | English (US) |
---|---|
Pages (from-to) | 4282-4285 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 14 |
Issue number | 16 |
DOIs | |
State | Published - Aug 17 2012 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry