Cytologic features of deep juvenile xanthogranuloma

Ronald T. Grenko, Joshua Z. Sickel, Catherine S. Abendroth, Robert E. Cilley

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19 Scopus citations


Juvenile xanthogranuloma (JXG) is a rare lesion of the skin and deep tissues whose cytologic features have not previously been published. We report on 2 cases of JXG in patients aged 5 days and 5 yr who presented with an axillary mass and enlarged supraclavicular lymph node, respectively. Fine- needle aspiration and touch imprints made from the surgical biopsies yielded cellular specimens composed of histiocytes, multinucleated Touton-type giant cells, and variable admixtures of lymphocytes and eosinophils. One lesion was composed primarily of benign-appearing histiocytes with admixed multinucleated giant cells and a few lymphocytes. The second lesion consisted of a few histiocytes, occasional Touton giant cells, many lymphocytes, and scattered fibroblasts. The histiocytes were CD68-positive and S100-negative. Histologic follow-up confirmed the diagnosis of juvenile xanthogranuloma. One patient was lost to follow-up; the other is alive without evidence of recurrence 1 yr after surgery. We conclude that deep JXG has characteristic and diagnostic cytologic features.

Original languageEnglish (US)
Pages (from-to)329-333
Number of pages5
JournalDiagnostic Cytopathology
Issue number4
StatePublished - Nov 1 1996

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology


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