Cytolytic T lymphocyte clones in anti-viral immunity: Effector function in vivo and mechanism of action

Table 2 SPECIFICITY OF PULMONARY VIRUS REDUCTION BY CTL CLONE Table 3 H-2 RESTRICTION OF RECOVERY MEDIATED BY CLONE A7 A/MEL/35 infected mice (Figure IB). The in vitro protective function of these cloned cells correlated with their capacity to eliminate infectious virus from the lungs of lethally infected recipient mice. As Table 2 demonstrates, clone A4 reduced pulmonary virus titers at day 5 after infection in an antigen-specific manner. This effect on virus titer paralleled the in vitro antigenic specificity of the clone and the specificity of its protective effect in vivo. Recovered mice showed no gross evidence of residual pulmonary pathology when lungs were examined at 21 to 28 days after infection. Thus, these cloned CTL which had been maintained in continuous in vitro culture for up to a year could reduce pulmonary virus titers and promote recovery from lethal infection in a fashion analogous to conventional heterogeneous CTL populations.