DAP-2, the Drosophila homolog of transcription factor AP-2

Ignacio Monge, Pamela J. Mitchell

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Transcription factor AP-2 is essential for craniofacial, nervous system, and limb development in the mouse. We report here the cloning and expression pattern analysis of DAP-2, the Drosophila homolog of AP-2 family genes. DAP- 2 is expressed in discrete regions of procephalic neuroectoderm, the brain ventral nerve cord, and maxillary segment during Drosophila embryogenesis, and in the brain, optic-lobes, ventral nerve cord, antenno-maxillary complex, and antennal and leg imaginal disks in third instar larvae. Protein sequence conservation and parallels between the embryonic expression patterns of DAP- 2 and mammalian AP-2 family genes indicate that transcription factor AP-2 has been structurally and functionally conserved during metazoan evolution.

Original languageEnglish (US)
Pages (from-to)191-195
Number of pages5
JournalMechanisms of Development
Issue number1-2
StatePublished - Aug 1998

All Science Journal Classification (ASJC) codes

  • Embryology
  • Developmental Biology


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