TY - GEN
T1 - Data assimilation of glucose dynamics for use in the intensive care unit
AU - Sedigh-Sarvestani, Madineh
AU - Albers, David J.
AU - Gluckman, Bruce J.
PY - 2012
Y1 - 2012
N2 - We know much about the glucose regulatory system, yet the application of this knowledge is limited because simultaneous measurements of insulin and glucose are difficult to obtain. We present a data assimilation framework for combining sparse measurements of the glucose regulatory system, available in the intensive care unit setting, with a nonlinear computational model to estimate unmeasured variables and unknown parameters. We also demonstrate a method for choosing the best variables for measurement. We anticipate that this framework will improve glucose maintenance therapies and shed light on the underlying biophysical process.
AB - We know much about the glucose regulatory system, yet the application of this knowledge is limited because simultaneous measurements of insulin and glucose are difficult to obtain. We present a data assimilation framework for combining sparse measurements of the glucose regulatory system, available in the intensive care unit setting, with a nonlinear computational model to estimate unmeasured variables and unknown parameters. We also demonstrate a method for choosing the best variables for measurement. We anticipate that this framework will improve glucose maintenance therapies and shed light on the underlying biophysical process.
UR - http://www.scopus.com/inward/record.url?scp=84870841557&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84870841557&partnerID=8YFLogxK
U2 - 10.1109/EMBC.2012.6347224
DO - 10.1109/EMBC.2012.6347224
M3 - Conference contribution
C2 - 23367159
AN - SCOPUS:84870841557
SN - 9781424441198
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 5437
EP - 5440
BT - 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012
T2 - 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012
Y2 - 28 August 2012 through 1 September 2012
ER -