Data-driven math model of FLT3-ITD acute myeloid leukemia reveals potential therapeutic targets

Keyphrases

• Acute Myeloid Leukemia 100%
• Math Model 100%
• Putative Drug Targets 100%
• Drug Treatment 50%
• Drug-induced 50%
• RNA-seq Data 50%
• Drug Response 50%
• System-wide 50%
• Acute Myeloid Leukemia Cells 50%
• FMS-like Tyrosine Kinase 3 (FLT3) 50%
• Biological Processes 25%
• Recurring 25%
• Clinical Response 25%
• Leukemia 25%
• Treatment Conditions 25%
• Poor Prognosis 25%
• Gene Regulatory Network 25%
• Dynamical Model 25%
• Gene Expression Changes 25%
• Overcoming Resistance 25%
• Acquired Resistance 25%
• Leukemia Cell Lines 25%
• Network Database 25%
• Gene Programs 25%
• Systems-level Understanding 25%
• Co-target 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Acute Myeloid Leukemia 100%
• Pharmacotherapy 33%
• Leukemia 16%
• Recurrent Disease 16%
• Dexamethasone 16%
• Diseases 16%
• Quizartinib 16%