Data on IL-10R neutralization-induced chronic colitis in Lipocalin 2 deficient mice on BALB/c background

Vishal Singh; Beng San Yeoh; Marit Nilsen-Hamilton; Thorsten Berger; Tak W. Mak; Matam Vijay-Kumar

doi:10.1016/j.dib.2017.03.002

Data on IL-10R neutralization-induced chronic colitis in Lipocalin 2 deficient mice on BALB/c background

Vishal Singh
, Beng San Yeoh
, Marit Nilsen-Hamilton
, Thorsten Berger
, Tak W. Mak
, Matam Vijay-Kumar

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The data herein is related to the research article entitled “Microbiota-inducible Innate Immune, Siderophore Binding Protein Lipocalin 2 is Critical for Intestinal Homeostasis” (Singh et al., 2016) [1] where we have demonstrated that C57BL/6 Lipocalin 2 deficient mice (Lcn2KO) developed chronic colitis upon anti-interleukin-10 receptor (αIL-10R) monoclonal antibody administration. In the present article, we evaluated the susceptibility of BALB/c Lcn2KO mice and their WT littermates to the αIL-10R neutralization-induced chronic colitis. Our data showed that αIL-10R mAb-treated BALB/c Lcn2KO mice exhibited severe chronic colitis (i.e., splenomegaly, colomegaly, colonic pathology, and incidence of rectal prolapse) when compared to WT mice.

Original language	English (US)
Pages (from-to)	588-592
Number of pages	5
Journal	Data in Brief
Volume	11
DOIs	https://doi.org/10.1016/j.dib.2017.03.002
State	Published - Apr 1 2017

All Science Journal Classification (ASJC) codes

General

Access to Document

10.1016/j.dib.2017.03.002

Cite this

@article{3fc0ae03fdcd48ce8bd6f21090d2b95e,

title = "Data on IL-10R neutralization-induced chronic colitis in Lipocalin 2 deficient mice on BALB/c background",

abstract = "The data herein is related to the research article entitled “Microbiota-inducible Innate Immune, Siderophore Binding Protein Lipocalin 2 is Critical for Intestinal Homeostasis” (Singh et al., 2016) [1] where we have demonstrated that C57BL/6 Lipocalin 2 deficient mice (Lcn2KO) developed chronic colitis upon anti-interleukin-10 receptor (αIL-10R) monoclonal antibody administration. In the present article, we evaluated the susceptibility of BALB/c Lcn2KO mice and their WT littermates to the αIL-10R neutralization-induced chronic colitis. Our data showed that αIL-10R mAb-treated BALB/c Lcn2KO mice exhibited severe chronic colitis (i.e., splenomegaly, colomegaly, colonic pathology, and incidence of rectal prolapse) when compared to WT mice.",

author = "Vishal Singh and Yeoh, \{Beng San\} and Marit Nilsen-Hamilton and Thorsten Berger and Mak, \{Tak W.\} and Matam Vijay-Kumar",

note = "Publisher Copyright: {\textcopyright} 2017 The Authors",

year = "2017",

month = apr,

day = "1",

doi = "10.1016/j.dib.2017.03.002",

language = "English (US)",

volume = "11",

pages = "588--592",

journal = "Data in Brief",

issn = "2352-3409",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Data on IL-10R neutralization-induced chronic colitis in Lipocalin 2 deficient mice on BALB/c background

AU - Singh, Vishal

AU - Yeoh, Beng San

AU - Nilsen-Hamilton, Marit

AU - Berger, Thorsten

AU - Mak, Tak W.

AU - Vijay-Kumar, Matam

PY - 2017/4/1

Y1 - 2017/4/1

N2 - The data herein is related to the research article entitled “Microbiota-inducible Innate Immune, Siderophore Binding Protein Lipocalin 2 is Critical for Intestinal Homeostasis” (Singh et al., 2016) [1] where we have demonstrated that C57BL/6 Lipocalin 2 deficient mice (Lcn2KO) developed chronic colitis upon anti-interleukin-10 receptor (αIL-10R) monoclonal antibody administration. In the present article, we evaluated the susceptibility of BALB/c Lcn2KO mice and their WT littermates to the αIL-10R neutralization-induced chronic colitis. Our data showed that αIL-10R mAb-treated BALB/c Lcn2KO mice exhibited severe chronic colitis (i.e., splenomegaly, colomegaly, colonic pathology, and incidence of rectal prolapse) when compared to WT mice.

AB - The data herein is related to the research article entitled “Microbiota-inducible Innate Immune, Siderophore Binding Protein Lipocalin 2 is Critical for Intestinal Homeostasis” (Singh et al., 2016) [1] where we have demonstrated that C57BL/6 Lipocalin 2 deficient mice (Lcn2KO) developed chronic colitis upon anti-interleukin-10 receptor (αIL-10R) monoclonal antibody administration. In the present article, we evaluated the susceptibility of BALB/c Lcn2KO mice and their WT littermates to the αIL-10R neutralization-induced chronic colitis. Our data showed that αIL-10R mAb-treated BALB/c Lcn2KO mice exhibited severe chronic colitis (i.e., splenomegaly, colomegaly, colonic pathology, and incidence of rectal prolapse) when compared to WT mice.

UR - https://www.scopus.com/pages/publications/85015371216

UR - https://www.scopus.com/pages/publications/85015371216#tab=citedBy

U2 - 10.1016/j.dib.2017.03.002

DO - 10.1016/j.dib.2017.03.002

M3 - Article

C2 - 28349107

AN - SCOPUS:85015371216

SN - 2352-3409

VL - 11

SP - 588

EP - 592

JO - Data in Brief

JF - Data in Brief

ER -

Data on IL-10R neutralization-induced chronic colitis in Lipocalin 2 deficient mice on BALB/c background

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this