Day-to-day variation in iron-status indexes in elderly women

Namanjeet Ahluwalia, Carol J. Lammi-Keefe, N. Rebecca Haley, John L. Beard

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43 Scopus citations


Day-to-day variability in biochemical indicators of iron status in well-hydrated and healthy women 70-79 y old (n = 10) was determined. Venous blood was collected on 4 nonconsecutive days during a 2-wk period. Analytical (σrep2) and biological (σfd2) variance components were computed based on a previously established scheme in younger adults. These two variance components were summed to obtain the total day-to-day variability (σfd2). Our results indicate that biological variation contributed most to the intraindividual variation. We calculated that sampling once for most iron indexes and twice for plasma transferrin receptors in elderly individuals is adequate to accurately determine these indexes whereas serum iron and transferrin saturation, indexes with high CVfd, require seven and eight measurements, respectively. These data, compared with previously published data in younger adults, demonstrate that aging is associated with a decreased variation in some indexes of iron status such as serum ferritin.

Original languageEnglish (US)
Pages (from-to)414-419
Number of pages6
JournalAmerican Journal of Clinical Nutrition
Issue number3
StatePublished - Mar 1993

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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