TY - JOUR
T1 - Decaffeinated green tea and voluntary exercise induce gene changes related to beige adipocyte formation in high fat-fed obese mice
AU - Sae-tan, Sudathip
AU - Rogers, Connie J.
AU - Lambert, Joshua D.
N1 - Funding Information:
The authors thank Drs. Zachary Bitzer, Sarah Forester, Yeyi Gu, and Tongtong Xu, and Ms. Ling Tao for technical assistance. This study was funded by NIH grant AT004678 (to JDL). Appendix
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - We have previously reported that decaffeinated green tea extract (GTE) in combination with voluntary exercise (Ex) reduces metabolic syndrome in high fat-fed C57BL/6J mice. Here, we examined for the first time the effect of treatment with 77 mg/g GTE, Ex, or both (GTE + Ex) on genes related to the conversion of white adipose tissue (WAT) to brown fat-like adipose tissue (BLAT) in this model. GTE + Ex induced genes related to lipolysis (hormone sensitive lipase [3.0-fold] and patatin-like phospholipase domain-containing protein 2 [2-fold]), mitochondrial β-oxidation (NADH dehydrogenase 5 [2.3-fold], cytochrome B [2.0-fold], and cytochrome C oxidase III [1.9-fold increase]), and adipose tissue browning (peroxisome proliferator-activated receptor-γ coactivator-1α [1.8-fold], bone morphogenetic protein 4 [2.6-fold], and phosphatase and tensin homolog [2.6-fold]) in visceral WAT compared to HF-fed mice. These results suggest that GTE + Ex function in part by inducing the conversion of WAT to BLAT and provides novel mechanistic insight into this combination.
AB - We have previously reported that decaffeinated green tea extract (GTE) in combination with voluntary exercise (Ex) reduces metabolic syndrome in high fat-fed C57BL/6J mice. Here, we examined for the first time the effect of treatment with 77 mg/g GTE, Ex, or both (GTE + Ex) on genes related to the conversion of white adipose tissue (WAT) to brown fat-like adipose tissue (BLAT) in this model. GTE + Ex induced genes related to lipolysis (hormone sensitive lipase [3.0-fold] and patatin-like phospholipase domain-containing protein 2 [2-fold]), mitochondrial β-oxidation (NADH dehydrogenase 5 [2.3-fold], cytochrome B [2.0-fold], and cytochrome C oxidase III [1.9-fold increase]), and adipose tissue browning (peroxisome proliferator-activated receptor-γ coactivator-1α [1.8-fold], bone morphogenetic protein 4 [2.6-fold], and phosphatase and tensin homolog [2.6-fold]) in visceral WAT compared to HF-fed mice. These results suggest that GTE + Ex function in part by inducing the conversion of WAT to BLAT and provides novel mechanistic insight into this combination.
UR - https://www.scopus.com/pages/publications/84926346402
UR - https://www.scopus.com/pages/publications/84926346402#tab=citedBy
U2 - 10.1016/j.jff.2015.01.036
DO - 10.1016/j.jff.2015.01.036
M3 - Article
AN - SCOPUS:84926346402
SN - 1756-4646
VL - 14
SP - 210
EP - 214
JO - Journal of Functional Foods
JF - Journal of Functional Foods
ER -