Deciphering the Molecular and Genetic Basis of Alzheimer’s Disease

Shamprasd Varija Raghu, Avinash Kundadka Kudva

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Alzheimer’s disease (AD) is a progressive age-related neurodegenerative disease in humans characterized by a decline in cognitive and personal daily activities. AD is considered a multifactorial disease involving different pathological and molecular phenotypes. Several risk factors like aging, genetic factors, infections, and environmental factors play in the onset of AD in humans. The advances in cellular biology have shed light on understanding the molecular mechanism underlying AD. However, current knowledge on the molecular pathogenesis of AD is complex and involves several hypotheses. Several genes and mutations are hallmarks of the molecular pathology of AD. These new discoveries on molecular pathogenesis and the involvement of genetic factors in AD are crucial because they will help us develop new therapeutic strategies for treating different conditions in AD. In the current chapter, we discuss the molecular mechanism inducing the onset of AD and the different genetic factors involved in it.

Original languageEnglish (US)
Title of host publicationFunctional Foods and Therapeutic Strategies for Neurodegenerative Disorders
PublisherSpringer Nature
Pages13-23
Number of pages11
ISBN (Electronic)9789811667039
ISBN (Print)9789811667022
DOIs
StatePublished - Jan 1 2022

All Science Journal Classification (ASJC) codes

  • General Medicine
  • General Neuroscience

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