TY - JOUR
T1 - Declining Adrenal Androgens
T2 - An Association with Bone Loss in Aging Women
AU - Wild, Robert A.
AU - Buchanan, James R.
AU - Myers, Cathleen
AU - Demers, Laurence M.
PY - 1987/12
Y1 - 1987/12
N2 - Bone loss in aging women is a major contributing factor to the onset of osteoporosis. To determine whether a decline in adrenal androgen output might be important in the loss of bone with age, we studied a highly selected group of 14 women, average age 70, and measured adrenal androgens in relationship to trabecular bone density. Dehydroepiandrosterone sulfate (DHEAS) levels were used as a marker of adrenal sex steroid output while quantitative, computerized tomography was used to determine trabecular bone density. Our results showed that both bone density (r = −0.69, P < 0.01) and DHEAS levels (r = −0.68, P < 0.01) declined with age, and that DHEAS was positively correlated with bone density (r = 0.66, P = 0.01). These data emphasize the association of declining adrenal sex steroid production with declining bone density during the process of aging.
AB - Bone loss in aging women is a major contributing factor to the onset of osteoporosis. To determine whether a decline in adrenal androgen output might be important in the loss of bone with age, we studied a highly selected group of 14 women, average age 70, and measured adrenal androgens in relationship to trabecular bone density. Dehydroepiandrosterone sulfate (DHEAS) levels were used as a marker of adrenal sex steroid output while quantitative, computerized tomography was used to determine trabecular bone density. Our results showed that both bone density (r = −0.69, P < 0.01) and DHEAS levels (r = −0.68, P < 0.01) declined with age, and that DHEAS was positively correlated with bone density (r = 0.66, P = 0.01). These data emphasize the association of declining adrenal sex steroid production with declining bone density during the process of aging.
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U2 - 10.3181/00379727-186-42625
DO - 10.3181/00379727-186-42625
M3 - Article
C2 - 2962200
AN - SCOPUS:0023611801
SN - 0037-9727
VL - 186
SP - 355
EP - 360
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
IS - 3
ER -