Decontamination of bioprocess equipment

Jack H. Young, William C. Lasher

Research output: Chapter in Book/Report/Conference proceedingConference contribution


A realistic approach is to experimentally determine sterilization/decontamination times for a limited number of parameters and develop a numerical model whose predicted values can be checked against experimental values. This study summarizes the status of work to develop general guidelines from both experimental and analytical studies. A 3l6L stainless steel tube was used to study effects of distance up the tube and tube orientation on temperature profiles and sterilization times. The finite element, model for the dead-end tube requires solution of the continuity, one species diffusion, energy and momentum equations. An expected rate of biological kill is computed from the temperature-concentration data and compared to experiemental results.

Original languageEnglish (US)
Title of host publicationBioprocess Engineering Symposium - 1991
PublisherPubl by ASME
Number of pages2
ISBN (Print)0791808947
StatePublished - 1991
EventWinter Annual Meeting of the American Society of Mechanical Engineers - Atlanta, GA, USA
Duration: Dec 1 1991Dec 6 1991


OtherWinter Annual Meeting of the American Society of Mechanical Engineers
CityAtlanta, GA, USA

All Science Journal Classification (ASJC) codes

  • Engineering(all)


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