TY - JOUR
T1 - Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease
AU - Simpson, Ian A.
AU - Chundu, Koteswara R.
AU - Davies‐Hill, Theresa
AU - Honer, William G.
AU - Davies, Peter
PY - 1994/5
Y1 - 1994/5
N2 - Glucose metabolism is depressed in the temporal and parietal regions of the cortex in patients with Alzheimer's disease. We measured the concentrations of two glucose transporters, GLUT1 and GLUT3, in six regions of brains from both control subjects and patients with Alzheimer's disease. The concentrations of both transporters were reduced in the cerebral cortex, with larger and highly significant reductions observed for GLUT3, the putative neuronal glucose transporter. The reductions in GLUT3 were greater than the loss of synapses, and should be considered as a potential cause of the deficits in glucose metabolism.
AB - Glucose metabolism is depressed in the temporal and parietal regions of the cortex in patients with Alzheimer's disease. We measured the concentrations of two glucose transporters, GLUT1 and GLUT3, in six regions of brains from both control subjects and patients with Alzheimer's disease. The concentrations of both transporters were reduced in the cerebral cortex, with larger and highly significant reductions observed for GLUT3, the putative neuronal glucose transporter. The reductions in GLUT3 were greater than the loss of synapses, and should be considered as a potential cause of the deficits in glucose metabolism.
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U2 - 10.1002/ana.410350507
DO - 10.1002/ana.410350507
M3 - Article
C2 - 8179300
AN - SCOPUS:0028241915
SN - 0364-5134
VL - 35
SP - 546
EP - 551
JO - Annals of Neurology
JF - Annals of Neurology
IS - 5
ER -