Decreased hepatic drug demethylation in patients receiving chemo‐immunotherapy

Allan Lipton; Gershon W. Hepner; Deborah S. White; Harold A. Harvey

doi:10.1002/1097-0142(197805)41:5<1680::AID-CNCR2820410506>3.0.CO;2-R

Decreased hepatic drug demethylation in patients receiving chemo‐immunotherapy

Allan Lipton, Gershon W. Hepner, Deborah S. White, Harold A. Harvey

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The effect of immunotherapy and chemotherapy on hepatic N‐demethylation of aminopyrine was studied by means of the aminopyrine breath test (ABT) in 32 patients with cancer. The aminopyrine breath test (ABT) was decreased in 3 of 11 patients (27.3%) receiving intradermal BCG (± DTIC) at a dose of 3 × 10⁷ viable organisms. One of 4 (25%) patients receiving intradermal BCG (± DTIC) at 3 × 10⁸ viable organisms per dose developed an altered ABT. Changes were not seen in patients receiving aerosol BCG (2 patients), intravenous C. parvum (2 patients), subcutaneous C. parvum (3 patients), and intravenous Cyclophosphamide (2 patients). Six of 7 patients (85.7%) receiving both intravenous C. parvum and Cyclophosphamide had a decreased ABT. These data indicate that chemo‐immunotherapy depressed hepatic aminopyrine N‐demethylation and suggests that patients treated with chemoimmunotherapy should be carefully observed for possible alterations of hepatic drug metabolism.

Original language	English (US)
Pages (from-to)	1680-1684
Number of pages	5
Journal	Cancer
Volume	41
Issue number	5
DOIs	https://doi.org/10.1002/1097-0142(197805)41:5<1680::AID-CNCR2820410506>3.0.CO;2-R
State	Published - May 1978

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/1097-0142(197805)41:5<1680::AID-CNCR2820410506>3.0.CO;2-R

Cite this

@article{8d5c6521647e40a0a5e739595278159d,

title = "Decreased hepatic drug demethylation in patients receiving chemo‐immunotherapy",

abstract = "The effect of immunotherapy and chemotherapy on hepatic N‐demethylation of aminopyrine was studied by means of the aminopyrine breath test (ABT) in 32 patients with cancer. The aminopyrine breath test (ABT) was decreased in 3 of 11 patients (27.3%) receiving intradermal BCG (± DTIC) at a dose of 3 × 107 viable organisms. One of 4 (25%) patients receiving intradermal BCG (± DTIC) at 3 × 108 viable organisms per dose developed an altered ABT. Changes were not seen in patients receiving aerosol BCG (2 patients), intravenous C. parvum (2 patients), subcutaneous C. parvum (3 patients), and intravenous Cyclophosphamide (2 patients). Six of 7 patients (85.7%) receiving both intravenous C. parvum and Cyclophosphamide had a decreased ABT. These data indicate that chemo‐immunotherapy depressed hepatic aminopyrine N‐demethylation and suggests that patients treated with chemoimmunotherapy should be carefully observed for possible alterations of hepatic drug metabolism.",

author = "Allan Lipton and Hepner, {Gershon W.} and White, {Deborah S.} and Harvey, {Harold A.}",

year = "1978",

month = may,

doi = "10.1002/1097-0142(197805)41:5<1680::AID-CNCR2820410506>3.0.CO;2-R",

language = "English (US)",

volume = "41",

pages = "1680--1684",

journal = "Cancer",

issn = "0008-543X",

publisher = "John Wiley and Sons Inc.",

number = "5",

}

TY - JOUR

T1 - Decreased hepatic drug demethylation in patients receiving chemo‐immunotherapy

AU - Lipton, Allan

AU - Hepner, Gershon W.

AU - White, Deborah S.

AU - Harvey, Harold A.

PY - 1978/5

Y1 - 1978/5

N2 - The effect of immunotherapy and chemotherapy on hepatic N‐demethylation of aminopyrine was studied by means of the aminopyrine breath test (ABT) in 32 patients with cancer. The aminopyrine breath test (ABT) was decreased in 3 of 11 patients (27.3%) receiving intradermal BCG (± DTIC) at a dose of 3 × 107 viable organisms. One of 4 (25%) patients receiving intradermal BCG (± DTIC) at 3 × 108 viable organisms per dose developed an altered ABT. Changes were not seen in patients receiving aerosol BCG (2 patients), intravenous C. parvum (2 patients), subcutaneous C. parvum (3 patients), and intravenous Cyclophosphamide (2 patients). Six of 7 patients (85.7%) receiving both intravenous C. parvum and Cyclophosphamide had a decreased ABT. These data indicate that chemo‐immunotherapy depressed hepatic aminopyrine N‐demethylation and suggests that patients treated with chemoimmunotherapy should be carefully observed for possible alterations of hepatic drug metabolism.

AB - The effect of immunotherapy and chemotherapy on hepatic N‐demethylation of aminopyrine was studied by means of the aminopyrine breath test (ABT) in 32 patients with cancer. The aminopyrine breath test (ABT) was decreased in 3 of 11 patients (27.3%) receiving intradermal BCG (± DTIC) at a dose of 3 × 107 viable organisms. One of 4 (25%) patients receiving intradermal BCG (± DTIC) at 3 × 108 viable organisms per dose developed an altered ABT. Changes were not seen in patients receiving aerosol BCG (2 patients), intravenous C. parvum (2 patients), subcutaneous C. parvum (3 patients), and intravenous Cyclophosphamide (2 patients). Six of 7 patients (85.7%) receiving both intravenous C. parvum and Cyclophosphamide had a decreased ABT. These data indicate that chemo‐immunotherapy depressed hepatic aminopyrine N‐demethylation and suggests that patients treated with chemoimmunotherapy should be carefully observed for possible alterations of hepatic drug metabolism.

UR - http://www.scopus.com/inward/record.url?scp=0018193694&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018193694&partnerID=8YFLogxK

U2 - 10.1002/1097-0142(197805)41:5<1680::AID-CNCR2820410506>3.0.CO;2-R

DO - 10.1002/1097-0142(197805)41:5<1680::AID-CNCR2820410506>3.0.CO;2-R

M3 - Article

C2 - 647621

AN - SCOPUS:0018193694

SN - 0008-543X

VL - 41

SP - 1680

EP - 1684

JO - Cancer

JF - Cancer

IS - 5

ER -

Decreased hepatic drug demethylation in patients receiving chemo‐immunotherapy

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this