Decreasing invasive pneumococcal disease in the elderly: A state-level analysis

A. Marshall McBean, Kyoungrae Jung, Paul L. Hebert

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Evidence has accumulated supporting the relationship between the use of 7-valent pneumococcal conjugate vaccine (PCV7) in children and a decline in invasive pneumococcal disease (IPD) in the elderly. We conducted a state-level analysis of vaccination coverage rates among children 19-35 months of age and IPD hospitalization rates among elderly Medicare beneficiaries. Simple correlations were suggestive of a negative relationship. Multivariate analysis using a state fixed-effect model which helped control for the time invariant factors at the state level also indicated a negative relationship, and it was statistically significant, p = 0.035. The relationship between the use of 23-valent pneumococcal polysaccharide vaccine (PPV23) and IPD hospitalizations was not statistically significant using either method.

Original languageEnglish (US)
Pages (from-to)5609-5614
Number of pages6
Issue number27-28
StatePublished - Jul 7 2006

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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