Decreasing invasive pneumococcal disease in the elderly: A state-level analysis

A. Marshall McBean; Kyoungrae Jung; Paul L. Hebert

doi:10.1016/j.vaccine.2006.04.055

Decreasing invasive pneumococcal disease in the elderly: A state-level analysis

A. Marshall McBean
, Kyoungrae Jung
, Paul L. Hebert

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Evidence has accumulated supporting the relationship between the use of 7-valent pneumococcal conjugate vaccine (PCV7) in children and a decline in invasive pneumococcal disease (IPD) in the elderly. We conducted a state-level analysis of vaccination coverage rates among children 19-35 months of age and IPD hospitalization rates among elderly Medicare beneficiaries. Simple correlations were suggestive of a negative relationship. Multivariate analysis using a state fixed-effect model which helped control for the time invariant factors at the state level also indicated a negative relationship, and it was statistically significant, p = 0.035. The relationship between the use of 23-valent pneumococcal polysaccharide vaccine (PPV23) and IPD hospitalizations was not statistically significant using either method.

Original language	English (US)
Pages (from-to)	5609-5614
Number of pages	6
Journal	Vaccine
Volume	24
Issue number	27-28
DOIs	https://doi.org/10.1016/j.vaccine.2006.04.055
State	Published - Jul 7 2006

All Science Journal Classification (ASJC) codes

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.vaccine.2006.04.055

Cite this

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title = "Decreasing invasive pneumococcal disease in the elderly: A state-level analysis",

abstract = "Evidence has accumulated supporting the relationship between the use of 7-valent pneumococcal conjugate vaccine (PCV7) in children and a decline in invasive pneumococcal disease (IPD) in the elderly. We conducted a state-level analysis of vaccination coverage rates among children 19-35 months of age and IPD hospitalization rates among elderly Medicare beneficiaries. Simple correlations were suggestive of a negative relationship. Multivariate analysis using a state fixed-effect model which helped control for the time invariant factors at the state level also indicated a negative relationship, and it was statistically significant, p = 0.035. The relationship between the use of 23-valent pneumococcal polysaccharide vaccine (PPV23) and IPD hospitalizations was not statistically significant using either method.",

author = "McBean, \{A. Marshall\} and Kyoungrae Jung and Hebert, \{Paul L.\}",

note = "Funding Information: Financial support was provided by the Centers for Medicare and Medicaid Services contract CMS 500-01-0043.",

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TY - JOUR

T1 - Decreasing invasive pneumococcal disease in the elderly

T2 - A state-level analysis

AU - McBean, A. Marshall

AU - Jung, Kyoungrae

AU - Hebert, Paul L.

N1 - Funding Information: Financial support was provided by the Centers for Medicare and Medicaid Services contract CMS 500-01-0043.

PY - 2006/7/7

Y1 - 2006/7/7

N2 - Evidence has accumulated supporting the relationship between the use of 7-valent pneumococcal conjugate vaccine (PCV7) in children and a decline in invasive pneumococcal disease (IPD) in the elderly. We conducted a state-level analysis of vaccination coverage rates among children 19-35 months of age and IPD hospitalization rates among elderly Medicare beneficiaries. Simple correlations were suggestive of a negative relationship. Multivariate analysis using a state fixed-effect model which helped control for the time invariant factors at the state level also indicated a negative relationship, and it was statistically significant, p = 0.035. The relationship between the use of 23-valent pneumococcal polysaccharide vaccine (PPV23) and IPD hospitalizations was not statistically significant using either method.

AB - Evidence has accumulated supporting the relationship between the use of 7-valent pneumococcal conjugate vaccine (PCV7) in children and a decline in invasive pneumococcal disease (IPD) in the elderly. We conducted a state-level analysis of vaccination coverage rates among children 19-35 months of age and IPD hospitalization rates among elderly Medicare beneficiaries. Simple correlations were suggestive of a negative relationship. Multivariate analysis using a state fixed-effect model which helped control for the time invariant factors at the state level also indicated a negative relationship, and it was statistically significant, p = 0.035. The relationship between the use of 23-valent pneumococcal polysaccharide vaccine (PPV23) and IPD hospitalizations was not statistically significant using either method.

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U2 - 10.1016/j.vaccine.2006.04.055

DO - 10.1016/j.vaccine.2006.04.055

M3 - Article

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JO - Vaccine

JF - Vaccine

IS - 27-28

ER -

Decreasing invasive pneumococcal disease in the elderly: A state-level analysis

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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