Deep Retinal Image Segmentation with Regularization under Geometric Priors

Venkateswararao Cherukuri, Vijay Kumar Bg, Raja Bala, Vishal Monga

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Vessel segmentation of retinal images is a key diagnostic capability in ophthalmology. This problem faces several challenges including low contrast, variable vessel size and thickness, and presence of interfering pathology such as micro-aneurysms and hemorrhages. Early approaches addressing this problem employed hand-crafted filters to capture vessel structures, accompanied by morphological post-processing. More recently, deep learning techniques have been employed with significantly enhanced segmentation accuracy. We propose a novel domain enriched deep network that consists of two components: 1) a representation network that learns geometric features specific to retinal images, and 2) a custom designed computationally efficient residual task network that utilizes the features obtained from the representation layer to perform pixel-level segmentation. The representation and task networks are jointly learned for any given training set. To obtain physically meaningful and practically effective representation filters, we propose two new constraints that are inspired by expected prior structure on these filters: 1) orientation constraint that promotes geometric diversity of curvilinear features, and 2) a data adaptive noise regularizer that penalizes false positives. Multi-scale extensions are developed to enable accurate detection of thin vessels. Experiments performed on three challenging benchmark databases under a variety of training scenarios show that the proposed prior guided deep network outperforms state of the art alternatives as measured by common evaluation metrics, while being more economical in network size and inference time.

Original languageEnglish (US)
Article number8868109
Pages (from-to)2552-2567
Number of pages16
JournalIEEE Transactions on Image Processing
StatePublished - 2020

All Science Journal Classification (ASJC) codes

  • Software
  • Computer Graphics and Computer-Aided Design


Dive into the research topics of 'Deep Retinal Image Segmentation with Regularization under Geometric Priors'. Together they form a unique fingerprint.

Cite this