Definition, acronyms, nomenclature, and classification of angioedema (DANCE): AAAAI, ACAAI, ACARE, and APAAACI DANCE consensus

Avner Reshef; Thomas Buttgereit; Stephen D. Betschel; Teresa Caballero; Henriette Farkas; Anete S. Grumach; Michihiro Hide; Ankur K. Jindal; Hilary Longhurst; Jonathan Peter; Marc A. Riedl; Yuxiang Zhi; Werner Aberer; Mohamed Abuzakouk; Tariq Al Farsi; Nashat Al Sukaiti; Mona Al-Ahmad; Sabine Altrichter; Emel Aygören-Pürsün; Maria Luisa Baeza; Noemi Anna Bara; Andrea Bauer; Jonathan A. Bernstein; Isabelle Boccon-Gibod; Hanna Bonnekoh; Laurence Bouillet; Zenon Brzoza; Anette Bygum; Oscar Calderon; Regis de Albuquerque Campos; Freya Helena Campos Romero; Mauro Cancian; Herberto Jose Chong-Neto; George Christoff; Stefan Cimbollek; Danny M. Cohn; Timothy Craig; Inna Danilycheva; Razvigor Darlenski; Aurélie Du-Thanh; Luis Felipe Ensina; Daria Fomina; Luz Fonacier; Atsushi Fukunaga; Asli Gelincik; Pedro Giavina-Bianchi; Kiran Godse; Mark Gompels; Margarida Goncalo; Maia Gotua; Guillermo Guidos-Fogelbach; Mar Guilarte; Alicja Kasperska-Zajac; Constance H. Katelaris; Tamar Kinaciyan; Pavel Kolkhir; Kanokvalai Kulthanan; Marcin Kurowski; Elena Latysheva; Antti Lauerma; David Launay; Ramon Lleonart; William Lumry; Alejandro Malbran; Ramzy Mohammed Ali; Iman Nasr; Sandra Nieto-Martinez; Claudio Parisi; Ruby Pawankar; Macarena Piñero-Saavedra; Todor A. Popov; Grzegorz Porebski; Alicia Prieto Garcia; Polina Pyatilova; Michael Rudenko; Bulent Enis Sekerel; Faradiba Sarquis Serpa; Farrukh Sheikh; Frank Siebenhaar; Angèle Soria; Maria Staevska; Petra Staubach; Marcin Stobiecki; Simon Francis Thomsen; Massimo Triggiani; Anna Valerieva; Solange Valle; Nguyen Van Dinh; Carolina Elisa Vera Ayala; Anna Zalewska-Janowska; Andrea Zanichelli; Markus Magerl; Marcus Maurer

doi:10.1016/j.jaci.2024.03.024

Definition, acronyms, nomenclature, and classification of angioedema (DANCE): AAAAI, ACAAI, ACARE, and APAAACI DANCE consensus

Avner Reshef, Thomas Buttgereit, Stephen D. Betschel, Teresa Caballero, Henriette Farkas, Anete S. Grumach, Michihiro Hide, Ankur K. Jindal, Hilary Longhurst, Jonathan Peter, Marc A. Riedl, Yuxiang Zhi, Werner Aberer, Mohamed Abuzakouk, Tariq Al Farsi, Nashat Al Sukaiti, Mona Al-Ahmad, Sabine Altrichter, Emel Aygören-Pürsün, Maria Luisa BaezaNoemi Anna Bara, Andrea Bauer, Jonathan A. Bernstein, Isabelle Boccon-Gibod, Hanna Bonnekoh, Laurence Bouillet, Zenon Brzoza, Anette Bygum, Oscar Calderon, Regis de Albuquerque Campos, Freya Helena Campos Romero, Mauro Cancian, Herberto Jose Chong-Neto, George Christoff, Stefan Cimbollek, Danny M. Cohn, Timothy Craig, Inna Danilycheva, Razvigor Darlenski, Aurélie Du-Thanh, Luis Felipe Ensina, Daria Fomina, Luz Fonacier, Atsushi Fukunaga, Asli Gelincik, Pedro Giavina-Bianchi, Kiran Godse, Mark Gompels, Margarida Goncalo, Maia Gotua, Guillermo Guidos-Fogelbach, Mar Guilarte, Alicja Kasperska-Zajac, Constance H. Katelaris, Tamar Kinaciyan, Pavel Kolkhir, Kanokvalai Kulthanan, Marcin Kurowski, Elena Latysheva, Antti Lauerma, David Launay, Ramon Lleonart, William Lumry, Alejandro Malbran, Ramzy Mohammed Ali, Iman Nasr, Sandra Nieto-Martinez, Claudio Parisi, Ruby Pawankar, Macarena Piñero-Saavedra, Todor A. Popov, Grzegorz Porebski, Alicia Prieto Garcia, Polina Pyatilova, Michael Rudenko, Bulent Enis Sekerel, Faradiba Sarquis Serpa, Farrukh Sheikh, Frank Siebenhaar, Angèle Soria, Maria Staevska, Petra Staubach, Marcin Stobiecki, Simon Francis Thomsen, Massimo Triggiani, Anna Valerieva, Solange Valle, Nguyen Van Dinh, Carolina Elisa Vera Ayala, Anna Zalewska-Janowska, Andrea Zanichelli, Markus Magerl, Marcus Maurer

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: Angioedema (AE) manifests with intermittent, localized, self-limiting swelling of the subcutaneous and/or submucosal tissue. AE is heterogeneous, can be hereditary or acquired, may occur only once or be recurrent, may exhibit wheals or not, and may be due to mast cell mediators, bradykinin, or other mechanisms. Several different taxonomic systems are currently used, making it difficult to compare the results of studies, develop multicenter collaboration, and harmonize AE treatment. Objective: We developed a consensus on the definition, acronyms, nomenclature, and classification of AE (DANCE). Methods: The initiative involved 91 experts from 35 countries and was endorsed by 53 scientific and medical societies, and patient organizations. A consensus was reached by online discussion and voting using the Delphi process over a period of 16 months (June 2021 to November 2022). Results: The DANCE initiative resulted in an international consensus on the definition, classification, and terminology of AE. The new consensus classification features 5 types and endotypes of AE and a harmonized vocabulary of abbreviations/acronyms. Conclusion: The DANCE classification complements current clinical guidelines and expert consensus recommendations on the diagnostic assessment and treatment of AE. DANCE does not replace current clinical guidelines, and expert consensus algorithms and should not be misconstrued in a way that affects reimbursement of medicines prescribed by physicians using sound clinical judgment. We anticipate that this new AE taxonomy and nomenclature will harmonize and facilitate AE research and clinical studies, thereby improving patient care.

Original language	English (US)
Pages (from-to)	398-411.e1
Journal	Journal of Allergy and Clinical Immunology
Volume	154
Issue number	2
DOIs	https://doi.org/10.1016/j.jaci.2024.03.024
State	Published - Aug 2024

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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10.1016/j.jaci.2024.03.024

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Reshef, A., Buttgereit, T., Betschel, S. D., Caballero, T., Farkas, H., Grumach, A. S., Hide, M., Jindal, A. K., Longhurst, H., Peter, J., Riedl, M. A., Zhi, Y., Aberer, W., Abuzakouk, M., Al Farsi, T., Al Sukaiti, N., Al-Ahmad, M., Altrichter, S., Aygören-Pürsün, E., ... Maurer, M. (2024). Definition, acronyms, nomenclature, and classification of angioedema (DANCE): AAAAI, ACAAI, ACARE, and APAAACI DANCE consensus. Journal of Allergy and Clinical Immunology, 154(2), 398-411.e1. https://doi.org/10.1016/j.jaci.2024.03.024

@article{dae8e7aac0ae4b7887b3eedb0f2f3163,

title = "Definition, acronyms, nomenclature, and classification of angioedema (DANCE): AAAAI, ACAAI, ACARE, and APAAACI DANCE consensus",

abstract = "Background: Angioedema (AE) manifests with intermittent, localized, self-limiting swelling of the subcutaneous and/or submucosal tissue. AE is heterogeneous, can be hereditary or acquired, may occur only once or be recurrent, may exhibit wheals or not, and may be due to mast cell mediators, bradykinin, or other mechanisms. Several different taxonomic systems are currently used, making it difficult to compare the results of studies, develop multicenter collaboration, and harmonize AE treatment. Objective: We developed a consensus on the definition, acronyms, nomenclature, and classification of AE (DANCE). Methods: The initiative involved 91 experts from 35 countries and was endorsed by 53 scientific and medical societies, and patient organizations. A consensus was reached by online discussion and voting using the Delphi process over a period of 16 months (June 2021 to November 2022). Results: The DANCE initiative resulted in an international consensus on the definition, classification, and terminology of AE. The new consensus classification features 5 types and endotypes of AE and a harmonized vocabulary of abbreviations/acronyms. Conclusion: The DANCE classification complements current clinical guidelines and expert consensus recommendations on the diagnostic assessment and treatment of AE. DANCE does not replace current clinical guidelines, and expert consensus algorithms and should not be misconstrued in a way that affects reimbursement of medicines prescribed by physicians using sound clinical judgment. We anticipate that this new AE taxonomy and nomenclature will harmonize and facilitate AE research and clinical studies, thereby improving patient care.",

author = "Avner Reshef and Thomas Buttgereit and Betschel, {Stephen D.} and Teresa Caballero and Henriette Farkas and Grumach, {Anete S.} and Michihiro Hide and Jindal, {Ankur K.} and Hilary Longhurst and Jonathan Peter and Riedl, {Marc A.} and Yuxiang Zhi and Werner Aberer and Mohamed Abuzakouk and {Al Farsi}, Tariq and {Al Sukaiti}, Nashat and Mona Al-Ahmad and Sabine Altrichter and Emel Ayg{\"o}ren-P{\"u}rs{\"u}n and Baeza, {Maria Luisa} and Bara, {Noemi Anna} and Andrea Bauer and Bernstein, {Jonathan A.} and Isabelle Boccon-Gibod and Hanna Bonnekoh and Laurence Bouillet and Zenon Brzoza and Anette Bygum and Oscar Calderon and {de Albuquerque Campos}, Regis and {Campos Romero}, {Freya Helena} and Mauro Cancian and Chong-Neto, {Herberto Jose} and George Christoff and Stefan Cimbollek and Cohn, {Danny M.} and Timothy Craig and Inna Danilycheva and Razvigor Darlenski and Aur{\'e}lie Du-Thanh and Ensina, {Luis Felipe} and Daria Fomina and Luz Fonacier and Atsushi Fukunaga and Asli Gelincik and Pedro Giavina-Bianchi and Kiran Godse and Mark Gompels and Margarida Goncalo and Maia Gotua and Guillermo Guidos-Fogelbach and Mar Guilarte and Alicja Kasperska-Zajac and Katelaris, {Constance H.} and Tamar Kinaciyan and Pavel Kolkhir and Kanokvalai Kulthanan and Marcin Kurowski and Elena Latysheva and Antti Lauerma and David Launay and Ramon Lleonart and William Lumry and Alejandro Malbran and Ali, {Ramzy Mohammed} and Iman Nasr and Sandra Nieto-Martinez and Claudio Parisi and Ruby Pawankar and Macarena Pi{\~n}ero-Saavedra and Popov, {Todor A.} and Grzegorz Porebski and {Prieto Garcia}, Alicia and Polina Pyatilova and Michael Rudenko and Sekerel, {Bulent Enis} and Serpa, {Faradiba Sarquis} and Farrukh Sheikh and Frank Siebenhaar and Ang{\`e}le Soria and Maria Staevska and Petra Staubach and Marcin Stobiecki and Thomsen, {Simon Francis} and Massimo Triggiani and Anna Valerieva and Solange Valle and {Van Dinh}, Nguyen and {Vera Ayala}, {Carolina Elisa} and Anna Zalewska-Janowska and Andrea Zanichelli and Markus Magerl and Marcus Maurer",

note = "Publisher Copyright: {\textcopyright} 2024",

year = "2024",

month = aug,

doi = "10.1016/j.jaci.2024.03.024",

language = "English (US)",

volume = "154",

pages = "398--411.e1",

journal = "Journal of Allergy and Clinical Immunology",

issn = "0091-6749",

publisher = "Elsevier Inc.",

number = "2",

}

Reshef, A, Buttgereit, T, Betschel, SD, Caballero, T, Farkas, H, Grumach, AS, Hide, M, Jindal, AK, Longhurst, H, Peter, J, Riedl, MA, Zhi, Y, Aberer, W, Abuzakouk, M, Al Farsi, T, Al Sukaiti, N, Al-Ahmad, M, Altrichter, S, Aygören-Pürsün, E, Baeza, ML, Bara, NA, Bauer, A, Bernstein, JA, Boccon-Gibod, I, Bonnekoh, H, Bouillet, L, Brzoza, Z, Bygum, A, Calderon, O, de Albuquerque Campos, R, Campos Romero, FH, Cancian, M, Chong-Neto, HJ, Christoff, G, Cimbollek, S, Cohn, DM, Craig, T, Danilycheva, I, Darlenski, R, Du-Thanh, A, Ensina, LF, Fomina, D, Fonacier, L, Fukunaga, A, Gelincik, A, Giavina-Bianchi, P, Godse, K, Gompels, M, Goncalo, M, Gotua, M, Guidos-Fogelbach, G, Guilarte, M, Kasperska-Zajac, A, Katelaris, CH, Kinaciyan, T, Kolkhir, P, Kulthanan, K, Kurowski, M, Latysheva, E, Lauerma, A, Launay, D, Lleonart, R, Lumry, W, Malbran, A, Ali, RM, Nasr, I, Nieto-Martinez, S, Parisi, C, Pawankar, R, Piñero-Saavedra, M, Popov, TA, Porebski, G, Prieto Garcia, A, Pyatilova, P, Rudenko, M, Sekerel, BE, Serpa, FS, Sheikh, F, Siebenhaar, F, Soria, A, Staevska, M, Staubach, P, Stobiecki, M, Thomsen, SF, Triggiani, M, Valerieva, A, Valle, S, Van Dinh, N, Vera Ayala, CE, Zalewska-Janowska, A, Zanichelli, A, Magerl, M & Maurer, M 2024, 'Definition, acronyms, nomenclature, and classification of angioedema (DANCE): AAAAI, ACAAI, ACARE, and APAAACI DANCE consensus', Journal of Allergy and Clinical Immunology, vol. 154, no. 2, pp. 398-411.e1. https://doi.org/10.1016/j.jaci.2024.03.024

TY - JOUR

T1 - Definition, acronyms, nomenclature, and classification of angioedema (DANCE)

T2 - AAAAI, ACAAI, ACARE, and APAAACI DANCE consensus

AU - Reshef, Avner

AU - Buttgereit, Thomas

AU - Betschel, Stephen D.

AU - Caballero, Teresa

AU - Farkas, Henriette

AU - Grumach, Anete S.

AU - Hide, Michihiro

AU - Jindal, Ankur K.

AU - Longhurst, Hilary

AU - Peter, Jonathan

AU - Riedl, Marc A.

AU - Zhi, Yuxiang

AU - Aberer, Werner

AU - Abuzakouk, Mohamed

AU - Al Farsi, Tariq

AU - Al Sukaiti, Nashat

AU - Al-Ahmad, Mona

AU - Altrichter, Sabine

AU - Aygören-Pürsün, Emel

AU - Baeza, Maria Luisa

AU - Bara, Noemi Anna

AU - Bauer, Andrea

AU - Bernstein, Jonathan A.

AU - Boccon-Gibod, Isabelle

AU - Bonnekoh, Hanna

AU - Bouillet, Laurence

AU - Brzoza, Zenon

AU - Bygum, Anette

AU - Calderon, Oscar

AU - de Albuquerque Campos, Regis

AU - Campos Romero, Freya Helena

AU - Cancian, Mauro

AU - Chong-Neto, Herberto Jose

AU - Christoff, George

AU - Cimbollek, Stefan

AU - Cohn, Danny M.

AU - Craig, Timothy

AU - Danilycheva, Inna

AU - Darlenski, Razvigor

AU - Du-Thanh, Aurélie

AU - Ensina, Luis Felipe

AU - Fomina, Daria

AU - Fonacier, Luz

AU - Fukunaga, Atsushi

AU - Gelincik, Asli

AU - Giavina-Bianchi, Pedro

AU - Godse, Kiran

AU - Gompels, Mark

AU - Goncalo, Margarida

AU - Gotua, Maia

AU - Guidos-Fogelbach, Guillermo

AU - Guilarte, Mar

AU - Kasperska-Zajac, Alicja

AU - Katelaris, Constance H.

AU - Kinaciyan, Tamar

AU - Kolkhir, Pavel

AU - Kulthanan, Kanokvalai

AU - Kurowski, Marcin

AU - Latysheva, Elena

AU - Lauerma, Antti

AU - Launay, David

AU - Lleonart, Ramon

AU - Lumry, William

AU - Malbran, Alejandro

AU - Ali, Ramzy Mohammed

AU - Nasr, Iman

AU - Nieto-Martinez, Sandra

AU - Parisi, Claudio

AU - Pawankar, Ruby

AU - Piñero-Saavedra, Macarena

AU - Popov, Todor A.

AU - Porebski, Grzegorz

AU - Prieto Garcia, Alicia

AU - Pyatilova, Polina

AU - Rudenko, Michael

AU - Sekerel, Bulent Enis

AU - Serpa, Faradiba Sarquis

AU - Sheikh, Farrukh

AU - Siebenhaar, Frank

AU - Soria, Angèle

AU - Staevska, Maria

AU - Staubach, Petra

AU - Stobiecki, Marcin

AU - Thomsen, Simon Francis

AU - Triggiani, Massimo

AU - Valerieva, Anna

AU - Valle, Solange

AU - Van Dinh, Nguyen

AU - Vera Ayala, Carolina Elisa

AU - Zalewska-Janowska, Anna

AU - Zanichelli, Andrea

AU - Magerl, Markus

AU - Maurer, Marcus

PY - 2024/8

Y1 - 2024/8

N2 - Background: Angioedema (AE) manifests with intermittent, localized, self-limiting swelling of the subcutaneous and/or submucosal tissue. AE is heterogeneous, can be hereditary or acquired, may occur only once or be recurrent, may exhibit wheals or not, and may be due to mast cell mediators, bradykinin, or other mechanisms. Several different taxonomic systems are currently used, making it difficult to compare the results of studies, develop multicenter collaboration, and harmonize AE treatment. Objective: We developed a consensus on the definition, acronyms, nomenclature, and classification of AE (DANCE). Methods: The initiative involved 91 experts from 35 countries and was endorsed by 53 scientific and medical societies, and patient organizations. A consensus was reached by online discussion and voting using the Delphi process over a period of 16 months (June 2021 to November 2022). Results: The DANCE initiative resulted in an international consensus on the definition, classification, and terminology of AE. The new consensus classification features 5 types and endotypes of AE and a harmonized vocabulary of abbreviations/acronyms. Conclusion: The DANCE classification complements current clinical guidelines and expert consensus recommendations on the diagnostic assessment and treatment of AE. DANCE does not replace current clinical guidelines, and expert consensus algorithms and should not be misconstrued in a way that affects reimbursement of medicines prescribed by physicians using sound clinical judgment. We anticipate that this new AE taxonomy and nomenclature will harmonize and facilitate AE research and clinical studies, thereby improving patient care.

AB - Background: Angioedema (AE) manifests with intermittent, localized, self-limiting swelling of the subcutaneous and/or submucosal tissue. AE is heterogeneous, can be hereditary or acquired, may occur only once or be recurrent, may exhibit wheals or not, and may be due to mast cell mediators, bradykinin, or other mechanisms. Several different taxonomic systems are currently used, making it difficult to compare the results of studies, develop multicenter collaboration, and harmonize AE treatment. Objective: We developed a consensus on the definition, acronyms, nomenclature, and classification of AE (DANCE). Methods: The initiative involved 91 experts from 35 countries and was endorsed by 53 scientific and medical societies, and patient organizations. A consensus was reached by online discussion and voting using the Delphi process over a period of 16 months (June 2021 to November 2022). Results: The DANCE initiative resulted in an international consensus on the definition, classification, and terminology of AE. The new consensus classification features 5 types and endotypes of AE and a harmonized vocabulary of abbreviations/acronyms. Conclusion: The DANCE classification complements current clinical guidelines and expert consensus recommendations on the diagnostic assessment and treatment of AE. DANCE does not replace current clinical guidelines, and expert consensus algorithms and should not be misconstrued in a way that affects reimbursement of medicines prescribed by physicians using sound clinical judgment. We anticipate that this new AE taxonomy and nomenclature will harmonize and facilitate AE research and clinical studies, thereby improving patient care.

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UR - http://www.scopus.com/inward/citedby.url?scp=85193505596&partnerID=8YFLogxK

U2 - 10.1016/j.jaci.2024.03.024

DO - 10.1016/j.jaci.2024.03.024

M3 - Article

C2 - 38670233

AN - SCOPUS:85193505596

SN - 0091-6749

VL - 154

SP - 398-411.e1

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 2

ER -

Definition, acronyms, nomenclature, and classification of angioedema (DANCE): AAAAI, ACAAI, ACARE, and APAAACI DANCE consensus

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