TY - JOUR
T1 - Delayed glans necrosis after circumcision
T2 - Role of testosterone in salvaging glans
AU - Aminsharifi, Alireza
AU - Afsar, Firouzeh
AU - Tourchi, Ali
N1 - Funding Information:
Acknowledgements This work was supported by the Shiraz University of Medical Sciences. We thank Dr Walid A. Farhat for his valuable comments and K. Shashok (AuthorAID in the Eastern Mediterranean) for improving the use of English in the manuscript.
PY - 2013/9
Y1 - 2013/9
N2 - Glans necrosis is a rare complication after circumcision and may occur secondary to cautery. The treatment of choice for glanular necrosis has not yet been established. The authors describe two cases of severe glanular ischemic necrosis that occurred after circumcision. The patients were successfully managed with 10 % testosterone cream for 4 wk. After completing the treatment course, the glans looked acceptable in size but the urethra sloughed partially and became hypospadic in one case. The authors hypothesize that the testosterone impact on endothelial cells and vascular endothelial growth factor expression may increase the penile blood supply and induce adequate revascularization of the glans; the effect that has been previously shown in experimental in vitro studies.
AB - Glans necrosis is a rare complication after circumcision and may occur secondary to cautery. The treatment of choice for glanular necrosis has not yet been established. The authors describe two cases of severe glanular ischemic necrosis that occurred after circumcision. The patients were successfully managed with 10 % testosterone cream for 4 wk. After completing the treatment course, the glans looked acceptable in size but the urethra sloughed partially and became hypospadic in one case. The authors hypothesize that the testosterone impact on endothelial cells and vascular endothelial growth factor expression may increase the penile blood supply and induce adequate revascularization of the glans; the effect that has been previously shown in experimental in vitro studies.
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U2 - 10.1007/s12098-012-0820-y
DO - 10.1007/s12098-012-0820-y
M3 - Article
C2 - 22752705
AN - SCOPUS:84884350576
SN - 0019-5456
VL - 80
SP - 791
EP - 793
JO - Indian Journal of Pediatrics
JF - Indian Journal of Pediatrics
IS - 9
ER -