TY - JOUR
T1 - Delayed sequelae after acute overdoses or poisonings
T2 - Cranial neuropathy related to ethylene glycol ingestion
AU - Lewis, Lionel D.
AU - Smith, Brian W.
AU - Mamourian, Alexander
PY - 1997/6/1
Y1 - 1997/6/1
N2 - A 31-year-old woman came to the hospital with breathlessness, confusion, and a refractory anion gap metabolic acidosis; acute renal failure subsequently developed. Her blood ethylene glycol concentration was 390 mg/L, and she was treated with an intravenous ethanol infusion and hemodialysis. During the tenth and eleventh day after admission bilateral seventh cranial nerve paralysis developed, as well as bilateral dysfunction of cranial nerves II, V, VIII, IX, X, and XII. Magnetic resonance imaging of her head showed gadolinium enhancement of the fifth cranial nerve bilaterally and a communicating hydrocephalus. Over the subsequent 11 months she recovered full function of her cranial nerves V, VII, IX, X, and XII, and she had subjective clinical improvement to baseline function in cranial nerves II and VIII. This case serves to introduce a discussion of agents that cause delayed complications after their acute toxic ingestion.
AB - A 31-year-old woman came to the hospital with breathlessness, confusion, and a refractory anion gap metabolic acidosis; acute renal failure subsequently developed. Her blood ethylene glycol concentration was 390 mg/L, and she was treated with an intravenous ethanol infusion and hemodialysis. During the tenth and eleventh day after admission bilateral seventh cranial nerve paralysis developed, as well as bilateral dysfunction of cranial nerves II, V, VIII, IX, X, and XII. Magnetic resonance imaging of her head showed gadolinium enhancement of the fifth cranial nerve bilaterally and a communicating hydrocephalus. Over the subsequent 11 months she recovered full function of her cranial nerves V, VII, IX, X, and XII, and she had subjective clinical improvement to baseline function in cranial nerves II and VIII. This case serves to introduce a discussion of agents that cause delayed complications after their acute toxic ingestion.
UR - http://www.scopus.com/inward/record.url?scp=0030994459&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030994459&partnerID=8YFLogxK
U2 - 10.1016/S0009-9236(97)90105-3
DO - 10.1016/S0009-9236(97)90105-3
M3 - Article
C2 - 9209253
AN - SCOPUS:0030994459
SN - 0009-9236
VL - 61
SP - 692
EP - 699
JO - Clinical pharmacology and therapeutics
JF - Clinical pharmacology and therapeutics
IS - 6
ER -