@article{5d2db70494714207bf93de29ce06a144,
title = "Deletion of p120-Catenin Results in a Tumor Microenvironment with Inflammation and Cancer that Establishes It as a Tumor Suppressor Gene",
abstract = "p120-catenin (p120ctn) interacts with E-cadherin, but to our knowledge, no formal proof that p120ctn functions as a bona fide tumor suppressor gene has emerged to date. We report herein that p120ctn loss leads to tumor development in mice. We have generated a conditional knockout model of p120ctn whereby mice develop preneoplastic and neoplastic lesions in the oral cavity, esophagus, and squamous forestomach. Tumor-derived cells secrete granulocyte macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), monocyte chemotactic protein-1 (MCP-1), and tumor necrosis factor-α (TNFα). The tumors contain significant desmoplasia and immune cell infiltration. Immature myeloid cells comprise a significant percentage of the immune cells present and likely participate in fostering a favorable tumor microenvironment, including the activation of fibroblasts.",
author = "Stairs, {Douglas B.} and Bayne, {Lauren J.} and Ben Rhoades and Vega, {Maria E.} and Waldron, {Todd J.} and Jiri Kalabis and Andres Klein-Szanto and Lee, {Ju Seog} and Katz, {Jonathan P.} and Diehl, {J. Alan} and Reynolds, {Albert B.} and Vonderheide, {Robert H.} and Rustgi, {Anil K.}",
note = "Funding Information: This work was supported by the following NIH grants: NCI P01-CA098101 Mechanisms in Esophageal Carcinogenesis (to D.B.S., J.K., M.E.V., J.P.K., A.K.-S., J.A.D., and A.K.R.); NCI F32-CA1308513 and NCI K99/R00-CA138498 (to D.B.S.); NCI T32-CA115299 (to J.K.); NCI U01-CA143056 (to A.K.R.); NCI P30 Abramson Cancer Center pilot grant NCI P30-CA016520 (to R.H.V.); NIDDK R01-DK069984 (to J.P.K.); and the NIDDK P30-DK050306 Center for Molecular Studies in Digestive and Liver Diseases and the American Cancer Society Research Professorship (to A.K.R.). Work contributed by the Reynolds lab was supported by NCI CA111947, CA055724, and the Vanderbilt GI SPORE (50CA95103). We wish to thank the Morphology (S. Mitchell), Molecular Biology/Gene Expression, Transgenic/Chimeric Mouse, Microarray and Cell Culture Core Facilities as well as Amy Ziober in the Department of Pathology and Laboratory Medicine. We are also grateful to members of the Rustgi lab for helpful discussions. ",
year = "2011",
month = apr,
day = "12",
doi = "10.1016/j.ccr.2011.02.007",
language = "English (US)",
volume = "19",
pages = "470--483",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "4",
}