@article{6f09f4bd2ed744809cf7923d79b12e95,
title = "Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy",
abstract = "We found the voltage-gated K+ channel Kv12.2 to be a potent regulator of excitability in hippocampal pyramidal neurons. Genetic deletion and pharmacologic block of Kv12.2 substantially reduced the firing threshold of these neurons. Kv12.2-/- (also known as Kcnh3-/-) mice showed signs of persistent neuronal hyperexcitability including frequent interictal spiking, spontaneous seizures and increased sensitivity to the chemoconvulsant pentylenetetrazol.",
author = "Xiaofei Zhang and Federica Bertaso and Yoo, {Jong W.} and Karsten Baumg{\"a}rtel and Clancy, {Sinead M.} and Van Lee and Cynthia Cienfuegos and Carly Wilmot and Jacqueline Avis and Truc Hunyh and Catherine Daguia and Christian Schmedt and Jeffrey Noebels and Timothy Jegla",
note = "Funding Information: Institute of Neurological Disorders and Stroke grants awarded to T.J. and J.N., an American Heart Association fellowship supporting X.Z. and INSERM funds supporting F.B. Funding Information: Lentivirus vectors were kindly provided by A. Maximov. The project was funded by the Genomics Institute of the Novartis Research Foundation, US National",
year = "2010",
month = sep,
doi = "10.1038/nn.2610",
language = "English (US)",
volume = "13",
pages = "1056--1058",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Research",
number = "9",
}